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Rabbit Polyclonal MAK Antibody

  • 中文名: MAK抗体
  • 别    名: Serine/threonine-protein kinase MAK, Male germ cell-associated kinase, MAK
货号: IPDX30036
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSerine/threonine-protein kinase MAK, Male germ cell-associated kinase, MAK
Entrez GeneID4117
WB Predicted band size70.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis MAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 578-608 amino acids from the C-terminal region of human MAK.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下为关于MAK抗体的示例参考文献(注:内容为基于学术知识构建的示例,建议通过PubMed等平台查询真实文献):

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1. **文献名称**:*The Role of MAK Kinase in Retinal Photoreceptor Ciliogenesis*

**作者**:Omori Y, et al.

**摘要**:研究揭示了MAK激酶在视网膜感光细胞纤毛形成中的关键作用,通过基因敲除实验发现MAK缺失导致纤毛结构异常,提示其与视网膜退行性疾病的相关性。

2. **文献名称**:*MAK as a Novel Biomarker in Hepatocellular Carcinoma*

**作者**:Chen L, et al.

**摘要**:该文献通过免疫组化分析发现MAK抗体在肝癌组织中高表达,且与患者预后不良相关,提示MAK可能作为肝癌诊断或治疗的潜在靶点。

3. **文献名称**:*MAK Antibody-Based Detection of Sperm Development Defects*

**作者**:Sato K, et al.

**摘要**:研究利用MAK抗体标记小鼠睾丸组织,证实MAK蛋白在精子发生过程中的动态表达,其异常表达与雄性不育症存在关联。

4. **文献名称**:*MAK Regulates Cell Cycle Progression via CDK1 Interaction*

**作者**:Wang H, et al.

**摘要**:本文发现MAK通过磷酸化CDK1调控细胞周期G2/M期转换,MAK抗体阻断实验进一步验证了其在癌细胞增殖中的促进作用。

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建议通过**PubMed**、**Google Scholar**等平台以关键词“MAK antibody”“MAK kinase”查询最新研究。

背景信息

MAK (Male Germ Cell-Associated Kinase) antibody is a research tool targeting the MAK protein, a serine/threonine kinase encoded by the MAK gene located on chromosome 6p24.3. Initially identified in male germ cells, MAK is involved in regulating cellular processes such as cell cycle progression, apoptosis, and cilia formation. Its role extends beyond reproductive biology, with emerging links to cancer progression and retinal degeneration. In oncology, MAK overexpression has been observed in hepatocellular carcinoma, prostate cancer, and colorectal cancer, where it may promote tumor growth, metastasis, and chemoresistance by modulating pathways like MAPK/ERK and Hippo-YAP. MAK antibodies are widely used in immunohistochemistry, Western blotting, and immunofluorescence to study protein expression patterns, subcellular localization, and functional mechanisms in disease models. In retinal research, MAK mutations are associated with retinitis pigmentosa, driving studies on its role in photoreceptor maintenance. Despite its diverse roles, MAK's precise molecular interactions remain under investigation, with antibodies serving as critical tools to unravel its pathophysiological significance and therapeutic potential.

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