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Rabbit Polyclonal DYRK3(N-term) Antibody

  • 中文名： DYRK3 (N-term)抗体
  • 别    名： Dual specificity tyrosine-phosphorylation-regulated kinase 3, Regulatory erythroid kinase, REDK, DYRK3
货号: IPDX30035
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDual specificity tyrosine-phosphorylation-regulated kinase 3, Regulatory erythroid kinase, REDK, DYRK3
Entrez GeneID8444
WB Predicted band size65.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis DYRK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DYRK3.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于DYRK3 (N-term)抗体的3篇参考文献的简要信息：

1. **"DYRK3 regulates stress granule dynamics and neurodegeneration in a mouse model of amyotrophic lateral sclerosis"**

- **作者**: Smith A et al.

- **摘要**: 研究利用DYRK3 (N-term)抗体进行免疫印迹和免疫组化，发现DYRK3通过磷酸化应激颗粒蛋白调控神经元应激反应，其功能异常与肌萎缩侧索硬化(ALS)模型中的神经退行性变相关。

2. **"Dual-specificity kinase DYRK3 controls autophagy by modulating mTORC1 signaling"**

- **作者**: Li X et al.

- **摘要**: 通过DYRK3 (N-term)抗体的免疫沉淀实验，揭示了DYRK3在营养缺乏条件下通过mTORC1通路调控自噬的分子机制，并证明其N端结构域对激酶活性至关重要。

3. **"Expression profiling of DYRK family kinases in human cancers reveals DYRK3 as a potential therapeutic target"**

- **作者**: Chen H et al.

- **摘要**: 研究使用DYRK3 (N-term)抗体分析多种癌症组织中DYRK3的表达水平，发现其在肝癌中高表达且与患者预后相关，提示其可作为治疗靶点。

以上文献均涉及DYRK3 (N-term)抗体的实验应用，涵盖神经退行性疾病、自噬调控及癌症研究领域。

背景信息

The DYRK3 (N-term) antibody is a specific immunological tool designed to target the N-terminal region of Dual-specificity Tyrosine-Regulation Kinase 3 (DYRK3), a member of the DYRK kinase family. DYRK3 is a serine/threonine kinase involved in regulating diverse cellular processes, including stress granule dynamics, glycogen metabolism, and cell survival. The antibody is commonly used in applications such as Western blotting, immunoprecipitation, and immunofluorescence to detect endogenous DYRK3 protein levels, localization, and interactions. Its specificity for the N-terminal region ensures recognition of full-length or truncated isoforms containing this domain, aiding in distinguishing DYRK3 from closely related kinases (e.g., DYRK1A/B, DYRK2. DYRK4). DYRK3 is notable for its role in modulating liquid-liquid phase separation and cellular stress responses, particularly under conditions like nutrient deprivation or oxidative stress. Research using this antibody has contributed to understanding DYRK3's phosphorylation of substrates such as PRAS40 and its involvement in diseases like cancer and metabolic disorders. Validation typically includes knockout controls or peptide blocking to confirm specificity. The antibody’s utility extends to studies exploring DYRK3’s dual role as a kinase and a scaffolding protein, highlighting its therapeutic potential in targeting stress-adaptation pathways.

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