| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SKI family transcriptional corepressor 2, Functional Smad-suppressing element on chromosome 18, Fussel-18, LBX1 corepressor 1-like protein, Ladybird homeobox corepressor 1-like protein, SKOR2, CORL2, FUSSEL18 |
| Entrez GeneID | 652991 |
| WB Predicted band size | 105.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This SKOR2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 741-775 amino acids from the C-terminal region of human SKOR2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SKOR2抗体的3篇代表性文献摘要(示例基于文献主题，非真实文献)：
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1. **标题**: "SKOR2 modulates neuronal excitability in the mouse cerebellum"
**作者**: Zhang L, et al.
**摘要**: 本研究利用特异性SKOR2抗体进行免疫组化，发现SKOR2蛋白在小脑浦肯野细胞中高表达，并通过电生理实验证明其通过调控钾离子通道影响神经元兴奋性。抗体验证显示在小鼠脑组织裂解液中检测到约50 kDa的单一条带。
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2. **标题**: "Developmental regulation of SKOR2/KCNK17 in the mammalian spinal cord"
**作者**: Gomez-Casati ME, et al.
**摘要**: 通过Western blot和免疫荧光技术，使用兔源SKOR2抗体揭示了该蛋白在胚胎期脊髓运动神经元中的动态表达模式，提示其可能参与运动神经回路发育。抗体特异性通过siRNA敲降实验验证。
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3. **标题**: "SKOR2 as a potential biomarker in neuropathic pain models"
**作者**: Kim H, et al.
**摘要**: 研究利用SKOR2抗体检测大鼠背根神经节中的表达变化，发现神经损伤后SKOR2表达显著上调，提示其可能通过调节超极化电流参与疼痛信号传导。抗体在组织切片中显示出特异性神经元膜定位。
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**备注**：以上文献为模拟示例，实际引用需查询PubMed等数据库(关键词：SKOR2 antibody, KCNK17)。建议补充具体实验需求(如物种、应用场景)以获取更精准的文献。
The SKOR2 antibody targets the SKOR2 protein (also known as FAM48B), a member of the SKI family transcriptional coregulators. SKOR2 is primarily expressed in the central nervous system and plays a critical role in neuronal development, particularly in the differentiation of spinal cord neurons. It functions as a transcriptional repressor, interacting with DNA-binding proteins and chromatin modifiers to regulate gene expression during neurogenesis. Research has linked SKOR2 to neural circuit formation and motor neuron specification, with its dysregulation implicated in neurological disorders and cancers, such as medulloblastoma.
SKOR2 antibodies are widely used in neuroscience and cancer research to study protein expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate SKOR2’s role in developmental pathways (e.g., BMP and Wnt signaling) and disease mechanisms. Recent studies also explore SKOR2’s potential as a biomarker or therapeutic target. When selecting SKOR2 antibodies, validation for specificity in relevant species (human, mouse) and applications is essential. Ongoing research continues to uncover its interactions with other regulatory proteins and its broader impact on cellular differentiation and disease pathology.
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