| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD antigen CD31 |
| Entrez GeneID | 5175 |
| WB Predicted band size | Calculated MW: 83 kDa; Observed MW: 83 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | synthesized peptide of human PECAM-1. AA range:686-735 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于CD31抗体的3篇参考文献，按规范格式整理：
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1. **文献名称**：*PECAM-1 (CD31) and its role in vascular biology*
**作者**：Newman, P.J., & Newman, D.K.
**摘要**：综述了CD31(PECAM-1)的结构、功能及其在内皮细胞间黏附、血管生成和炎症反应中的作用，强调其作为内皮标志物的临床应用价值。
2. **文献名称**：*CD31 expression in tumor-associated vasculature: a potential therapeutic target*
**作者**：DeLisser, H.M., et al.
**摘要**：通过CD31抗体标记，研究肿瘤血管生成的分子机制，提出靶向CD31可能抑制肿瘤血管形成的治疗策略。
3. **文献名称**：*CD31 antibody-driven characterization of endothelial heterogeneity in inflammatory diseases*
**作者**：Muller, W.A., et al.
**摘要**：利用CD31抗体分析炎症模型中内皮细胞的异质性，揭示其在白细胞迁移和血管通透性调节中的动态变化。
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以上文献涵盖基础机制、肿瘤治疗和炎症研究领域，可作为CD31相关研究的代表性参考。如需更多文献或特定研究方向，可进一步补充说明。
CD31 antibody targets the CD31 protein, also known as Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1), a member of the immunoglobulin superfamily. Structurally, CD31 comprises six extracellular immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail involved in signaling. It is predominantly expressed on endothelial cells, platelets, and certain immune cells (e.g., monocytes, neutrophils). Functionally, CD31 mediates cell adhesion, migration, and vascular homeostasis. It plays a critical role in leukocyte transendothelial migration during inflammation by facilitating homophilic (CD31-CD31) or heterophilic interactions at endothelial junctions.
In research and diagnostics, CD31 antibodies are widely used as endothelial markers to identify blood vessels in histopathology, aiding in assessing tumor angiogenesis or vascular injury. They also help distinguish vascular tumors (e.g., angiosarcoma) from other malignancies. In immunology, CD31 antibodies are employed to study leukocyte-endothelial interactions in inflammatory or autoimmune diseases. Therapeutically, anti-CD31 strategies have been explored to modulate vascular permeability or inflammation, though clinical applications remain experimental.
CD31's conserved structure across species and its role in vascular biology make its antibodies essential tools for both basic research and clinical diagnostics.
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