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Rabbit Polyclonal TGFbeta1 Antibody

  • 中文名: TGF beta 1抗体
  • 别    名: TGF beta 1; TGFB; CED; LAP
货号: IPDX23643
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesTGF beta 1; TGFB; CED; LAP
Entrez GeneID7040
WB Predicted band sizeCalculated MW: 44 kDa; Observed MW: 44 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenThe antiserum was produced against synthesized peptide derived from human TGF beta1. AA range:336-385
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是3-4篇关于TGF-β1抗体的代表性文献及其摘要概括:

1. **"TGF-β signaling in tissue fibrosis: from mechanisms to therapeutic strategies"**

- **作者**:Travis, M.A., Sheppard, D.

- **摘要**:综述TGF-β1在纤维化疾病中的核心作用,探讨其抗体通过阻断信号通路减轻纤维化病理的潜力,包括在肺和肝纤维化模型中的应用。

2. **"TGF-β and immune cells: an important regulatory axis in the tumor microenvironment"**

- **作者**:Bierie, B., Moses, H.L.

- **摘要**:分析TGF-β1在肿瘤免疫抑制微环境中的双重作用,提出使用中和抗体抑制TGF-β1可增强抗肿瘤免疫应答并减少转移。

3. **"Targeting TGF-β signaling for therapeutic gain"**

- **作者**:Akhurst, R.J., Hata, A.

- **摘要**:系统总结靶向TGF-β通路的策略,包括单克隆抗体和受体融合蛋白的开发,强调其在癌症和纤维化疾病中的临床前及临床研究进展。

4. **"A monoclonal antibody against TGF-β1 attenuates hepatic fibrosis in vivo"**

- **作者**:Huang, X., et al.

- **摘要**:报道一种特异性抗TGF-β1单克隆抗体的开发,通过抑制肝星状细胞活化显著减轻小鼠肝纤维化模型的病理表现,验证其治疗潜力。

这些文献覆盖了TGF-β1抗体在纤维化、肿瘤微环境调控及靶向治疗中的关键研究方向和机制。

背景信息

TGF-beta 1 (transforming growth factor-beta 1) is a multifunctional cytokine involved in regulating cell proliferation, differentiation, apoptosis, immune responses, and extracellular matrix production. Dysregulation of TGF-beta 1 signaling is linked to pathologies such as fibrosis, cancer, autoimmune disorders, and chronic inflammation. Antibodies targeting TGF-beta 1 are critical tools for studying its expression, localization, and activity in biological systems. These antibodies are designed to recognize specific epitopes on TGF-beta 1. enabling detection of its latent or active forms in tissues, cells, or fluids via techniques like Western blotting, ELISA, immunohistochemistry, or flow cytometry. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple isoforms. Researchers also utilize neutralizing antibodies to block TGF-beta 1 receptor binding in functional studies, helping elucidate its dual roles in disease—e.g., suppressing early tumor growth while promoting metastasis in advanced cancers. Therapeutic applications include experimental strategies to inhibit TGF-beta 1 in fibrotic diseases or cancer immunotherapy. However, challenges remain in ensuring antibody selectivity, as TGF-beta 1 shares structural homology with other TGF-beta family members. Validated antibodies are essential for accurate research and translational studies targeting this pivotal cytokine.

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