| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MMP3; STMY1; Stromelysin-1; SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1 |
| Entrez GeneID | 4314 |
| WB Predicted band size | Calculated MW: 54 kDa; Observed MW: 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MMP-3. AA range:421-470 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于MMP3抗体的3篇参考文献的简要整理(基于模拟生成内容，非真实文献)：
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1. **"Monoclonal antibody targeting MMP3 suppresses collagen degradation in osteoarthritis models"**
*作者：Li, X. et al.*
**摘要**：研究开发了一种靶向MMP3的单克隆抗体，证实其通过抑制MMP3的蛋白酶活性，减少关节软骨胶原降解，在骨关节炎小鼠模型中改善病理进展。
2. **"MMP3-specific antibody inhibits tumor invasion and metastasis in triple-negative breast cancer"**
*作者：Garcia, R. et al.*
**摘要**：利用人源化MMP3抗体阻断肿瘤微环境中的MMP3活性，显著降低乳腺癌细胞侵袭能力，并抑制小鼠模型中的肺转移，提示其作为治疗靶点的潜力。
3. **"A novel MMP3-neutralizing antibody reduces fibrosis in cardiac remodeling"**
*作者：Sato, K. et al.*
**摘要**：通过中和MMP3抗体干预心肌梗死后心脏纤维化模型，发现其能减少细胞外基质过度沉积，改善心脏功能，为心衰治疗提供新策略。
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*注：以上文献为示例，实际引用需根据具体研究通过PubMed、Web of Science等数据库检索真实发表论文。*
Matrix metalloproteinase 3 (MMP3), also known as stromelysin-1. is a member of the MMP family of zinc-dependent endopeptidases involved in extracellular matrix (ECM) remodeling. It plays critical roles in physiological processes such as tissue repair, embryonic development, and immune response, as well as pathological conditions including cancer metastasis, arthritis, and cardiovascular diseases. MMP3 is secreted as an inactive zymogen (pro-MMP3) that requires proteolytic activation. Once active, it degrades ECM components like collagen, fibronectin, and proteoglycans, and activates other MMPs, amplifying ECM degradation cascades.
MMP3 antibodies are essential tools for detecting and quantifying MMP3 expression in research and diagnostics. They are widely used in techniques like ELISA, Western blotting, and immunohistochemistry to study MMP3's involvement in disease mechanisms. Elevated MMP3 levels are associated with tumor invasiveness, chronic inflammation, and tissue destruction, making it a biomarker for disease progression in cancers (e.g., breast, colorectal) and inflammatory disorders (e.g., rheumatoid arthritis). Therapeutic MMP3 inhibitors, including monoclonal antibodies, have been explored to block its proteolytic activity, though challenges remain in balancing efficacy with off-target effects due to MMP functional overlap. Research continues to optimize MMP3-specific targeting strategies for clinical applications.
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