WB | 咨询技术 | Human,Mouse,Rat,Pig |
IF | 咨询技术 | Human,Mouse,Rat,Pig |
IHC | 1/50-1/100 | Human,Mouse,Rat,Pig |
ICC | 1/50-1/200 | Human,Mouse,Rat,Pig |
FCM | 咨询技术 | Human,Mouse,Rat,Pig |
Elisa | 1/10000 | Human,Mouse,Rat,Pig |
Aliases | FOXO1; FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma |
Entrez GeneID | 2308 |
WB Predicted band size | Calculated MW: 70 kDa; Observed MW: 78 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat,Pig |
Immunogen | The antiserum was produced against synthesized peptide derived from human FKHR. AA range:223-272 |
Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇与FOXO1抗体相关的参考文献摘要(注:文献信息为模拟生成,仅供参考):
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1. **文献名称**:*FOXO1 regulates leukemia stem cell activity in T-cell acute lymphoblastic leukemia*
**作者**:Zhang Y. et al.
**摘要**:研究利用特异性FOXO1抗体(克隆号#ab5287)通过流式细胞术和Western blot分析,发现FOXO1在T-ALL白血病干细胞中异常激活,调控下游凋亡相关基因表达,提示其作为潜在治疗靶点。
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2. **文献名称**:*Immunohistochemical analysis of FOXO1 subcellular localization in diabetic nephropathy*
**作者**:Tanaka R. et al.
**摘要**:通过FOXO1单克隆抗体(Cell Signaling #2880)进行肾脏组织免疫组化染色,发现高血糖条件下FOXO1的核转位增加,与肾小球细胞凋亡及氧化应激水平正相关。
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3. **文献名称**:*Phosphorylation-dependent regulation of FOXO1 by AKT and AMPK*
**作者**:Chen L. et al.
**摘要**:研究采用抗FOXO1磷酸化抗体(Ser256位点,Santa Cruz #sc-101682)验证AKT和AMPK信号通路对FOXO1活性的调控机制,揭示其在代谢平衡中的双重作用。
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如需具体文献,建议通过PubMed或Web of Science以“FOXO1 antibody”及实验技术(如Western blot/IF)为关键词检索近年高引论文。
FOXO1 (Forkhead Box O1) is a transcription factor belonging to the FOXO family, which plays a critical role in regulating cellular processes such as apoptosis, cell cycle arrest, oxidative stress resistance, and metabolism. It functions as a tumor suppressor by integrating signals from pathways like PI3K/AKT, AMPK, and mTOR, which modulate its subcellular localization. When dephosphorylated, FOXO1 translocates to the nucleus, activating target genes involved in stress response and longevity. Dysregulation of FOXO1 is implicated in cancer, diabetes, and aging-related diseases.
FOXO1 antibodies are essential tools for studying its expression, localization, and activity in various biological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to investigate FOXO1's role in cellular signaling, disease mechanisms, and therapeutic responses. Specific FOXO1 antibodies can detect distinct post-translational modifications (e.g., phosphorylation at Ser256 or Thr24) to assess its activation status.
Research utilizing FOXO1 antibodies has advanced understanding of its dual roles in health and disease. For example, in cancer, FOXO1 suppression promotes tumor progression, while in metabolic disorders, its activation enhances insulin sensitivity. Validated FOXO1 antibodies are crucial for ensuring experimental reproducibility, with many studies confirming specificity via knockout controls or siRNA knockdown. Overall, FOXO1 antibodies remain indispensable for unraveling its complex regulatory networks and therapeutic potential.
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