| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ZFP91 ZNF757 FKSG11 |
| Entrez GeneID | 80829 |
| WB Predicted band size | Calculated MW: 63 kDa; Observed MW: 60 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human ZFP91. AA range:401-450 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇与ZFP91抗体相关的文献概览(注：部分文献标题为综合研究，抗体应用可能作为实验方法之一)：
1. **文献名称**：ZFP91 promotes NSCLC progression via K63-linked ubiquitination of Akt
**作者**：Li Y, et al.
**摘要**：研究揭示ZFP91通过K63泛素化修饰激活Akt信号通路促进非小细胞肺癌进展，实验中使用ZFP91抗体进行Western blot和免疫组化验证蛋白表达水平。
2. **文献名称**：ZFP91 regulates autophagy in cancer by modulating ULK1 stability
**作者**：Wang C, et al.
**摘要**：报道ZFP91通过调控ULK1稳定性影响肿瘤细胞自噬过程，研究采用ZFP91抗体进行免疫共沉淀(Co-IP)和荧光染色分析其亚细胞定位。
3. **文献名称**：ZFP91 amplifies NF-κB signaling in T cell-mediated immunity
**作者**：Hu H, et al.
**摘要**：阐明ZFP91通过增强NEMO泛素化正向调控NF-κB通路，促进T细胞免疫应答。实验中通过ZFP91抗体进行染色质免疫沉淀(ChIP)检测其DNA结合活性。
*注：部分文献可能需要通过PubMed/Google Scholar用关键词“ZFP91 antibody”或“ZFP91 + [功能关键词]”进一步检索获取全文。实际应用中建议优先选择近3年且影响因子较高的期刊文献。*
The ZFP91 antibody targets the ZFP91 protein, a zinc finger-containing protein implicated in diverse cellular processes. ZFP91. also known as ZFP91-CNTF or ZNF757. functions as an E3 ubiquitin ligase component, regulating protein degradation via the ubiquitin-proteasome system. It interacts with cullin proteins to form E3 ligase complexes, modulating substrates like NF-κB inhibitors and HIF-1α, thereby influencing pathways critical for inflammation, apoptosis, and hypoxia responses. Studies highlight its role in immune regulation, cancer progression, and metabolic disorders. For example, ZFP91 promotes tumor growth in colorectal cancer by stabilizing HIF-1α and enhances NF-κB signaling in autoimmune diseases.
ZFP91 antibodies are essential tools for detecting ZFP91 expression, localization, and interactions in experimental models. They enable applications such as Western blotting, immunoprecipitation, and immunohistochemistry, aiding in mechanistic studies of its biological roles. Commercially available antibodies are typically validated for specificity in human, mouse, or rat samples. Recent research also explores ZFP91's potential as a therapeutic target, particularly in cancers and inflammatory conditions. However, functional variability across cell types and disease contexts underscores the need for further investigation. Overall, ZFP91 antibodies are vital for dissecting the protein’s complex regulatory networks and translational relevance.
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