关键信息
-
基因名
GPRC5D
-
简介
G 蛋白偶联受体仅存在于真核生物中，包括酵母和鞭藻。结合并激活这些受体的配体包括光敏化合物、气味、信息素、激素和神经递质，其大小从小分子到多肽再到大蛋白质不等。G 蛋白偶联受体与许多疾病有关。G 蛋白偶联受体的信号转导途径包括 cAMP 信号通路和磷脂酰肌醇信号通路。GPRC5D 是一种偶联 G 蛋白的孤儿受体，与哺乳动物 G 蛋白偶联受体 (GPCRs) 超家族 C 家族第五组成员 (与代谢性谷氨酸受体样相关) 具有同源性。GPRC5D 是 CAR-T 细胞免疫治疗多发性骨髓瘤的靶点 GPRC5D Protein-Nanodisc, Cynomolgus (HEK293, His, Flag) is the recombinant cynomolgus-derived GPRC5D protein, expressed by HEK293, with C-His and N-Flag labeled tag.
- 应用
-
别名
GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor
-
种属
Cynomolgus
-
表达系统
HEK293
-
标签
C-His;N-Flag
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
A0A2K5W6I7 (M1-F192)&
-
表达区间
A0A2K5W6I7 (M1-F192)&(E191-L262)
-
分子量
37 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
