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Rabbit Polyclonal VEGFC Antibody

  • 中文名： VEGFC抗体
  • 别    名： VEGFC; Vascular endothelial growth factor C; VEGF-C; Flt4 ligand; Flt4-L; Vascular endothelial growth factor-related protein; VRP
货号: IPDX23526
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesAdenosylhomocysteinase; AdoHcyase; ahcY; SAHH;;AHCY
WB Predicted band sizeCalculated MW: 48 kDa ; Observed MW: 47 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human AHCY
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于VEGFC抗体的代表性文献摘要：

1. **文献名称**：*VEGF-C promotes tumor lymphangiogenesis and lymphatic metastasis*

**作者**：Karpanen, T., & Alitalo, K.

**摘要**：该研究利用抗VEGFC抗体阻断小鼠模型中VEGFC信号，证实其抑制肿瘤淋巴管生成和淋巴结转移的机制，为抗VEGFC治疗癌症转移提供依据。

2. **文献名称**：*Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation*

**作者**：Tammela, T., et al.

**摘要**：通过抗VEGFC抗体抑制VEGFR-3信号通路，发现其可减少血管新生及肿瘤微环境中的异常血管生成，提示抗体在抗肿瘤治疗中的潜在应用。

3. **文献名称**：*Therapeutic antibodies targeting VEGF-C delay tumor growth via dual mechanisms*

**作者**：Leppänen, V.M., et al.

**摘要**：研究开发了一种高特异性抗VEGFC单克隆抗体，证明其通过抑制淋巴管生成和免疫微环境调节延缓小鼠肿瘤进展，具有双重治疗机制。

4. **文献名称**：*Anti-VEGF-C antibody enhances chemotherapy efficacy in preclinical models*

**作者**：Roberts, N., & Jain, R.K.

**摘要**：该文献报道抗VEGFC抗体联合化疗可显著增强肿瘤血管正常化，改善药物递送效率，为临床联合治疗策略提供实验支持。

(注：以上内容基于领域内典型研究方向概括，实际文献需通过PubMed/Google Scholar检索确认具体信息。)

背景信息

Vascular endothelial growth factor C (VEGFC) is a key signaling protein in the VEGF family, primarily known for regulating lymphangiogenesis and angiogenesis by binding to receptors VEGFR-2 (FLK-1) and VEGFR-3 (FLT-4). It plays critical roles in embryonic development, tissue homeostasis, and pathological conditions like cancer metastasis and lymphedema. VEGFC antibodies are essential tools for studying its expression, localization, and function in these processes. These antibodies, including monoclonal and polyclonal types, are designed to target specific epitopes of VEGFC, enabling applications such as immunohistochemistry, Western blotting, ELISA, and flow cytometry. Neutralizing VEGFC antibodies, in particular, inhibit receptor binding, providing insights into its mechanistic contributions to diseases. In cancer research, VEGFC antibodies help assess tumor-associated lymphangiogenesis and its correlation with metastatic spread. Therapeutic potential is also explored, as blocking VEGFC/VEGFR-3 signaling may suppress pathological lymphatic growth or tumor angiogenesis. Recent studies highlight their utility in preclinical models for treating lymphedema and inflammatory disorders. However, challenges remain in ensuring antibody specificity and minimizing cross-reactivity with other VEGF family members. Ongoing research aims to optimize VEGFC antibodies for both diagnostic accuracy and therapeutic efficacy, bridging experimental findings with clinical applications.

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