| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ACTC1; ACTC; Actin; alpha cardiac muscle 1; Alpha-cardiac actin; ACTA1; ACTA; Actin; alpha skeletal muscle; Alpha-actin-1; ACTA2; ACTSA; ACTVS; GIG46 |
| Entrez GeneID | 70 |
| WB Predicted band size | Calculated MW: 42 kDa; Observed MW: 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human α-SMA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于ACTC1抗体的3篇虚构参考文献示例，涵盖其在不同研究中的应用：
1. **文献名称**：*"Immunohistochemical Detection of ACTC1 in Hypertrophic Cardiomyopathy"*
**作者**：Zhang, L. et al.
**摘要**：通过ACTC1特异性抗体进行免疫组化分析，揭示肥厚型心肌病患者心肌组织中ACTC1蛋白的异常聚集，提示其与疾病病理相关。
2. **文献名称**：*"Development and Validation of a High-Affinity ACTC1 Antibody for Cardiac Proteomics"*
**作者**：Müller, R. et al.
**摘要**：报道一种新型兔源多克隆ACTC1抗体的开发，经Western blot和质谱验证，证实其适用于心脏组织蛋白质组学研究，具有高灵敏度和低交叉反应性。
3. **文献名称**：*"ACTC1 Expression Dynamics in Zebrafish Heart Regeneration"*
**作者**：Tanaka, K. et al.
**摘要**：利用ACTC1抗体追踪斑马鱼心脏再生过程中该蛋白的时空表达变化，发现再生早期ACTC1表达上调，提示其在心肌修复中的潜在作用。
(注：以上文献为示例性内容，实际文献需通过学术数据库检索确认。)
The ACTC1 antibody targets actin alpha cardiac muscle 1 (ACTC1), a protein encoded by the ACTC1 gene, which is a crucial component of the contractile apparatus in cardiac and skeletal muscle cells. As a member of the actin family, ACTC1 polymerizes to form thin filaments that interact with myosin to enable muscle contraction. It is predominantly expressed in the heart, where it plays a vital role in maintaining structural integrity and mechanical function. ACTC1 mutations are linked to cardiomyopathies, such as hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), making the protein a focus of cardiovascular research.
The ACTC1 antibody is widely used in research to study cardiac development, disease mechanisms, and cytoskeletal dynamics. It aids in detecting ACTC1 expression levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. In pathological contexts, altered ACTC1 expression has been observed in heart failure and certain cancers, suggesting potential roles beyond muscle contraction. Additionally, the antibody serves as a tool to investigate ACTC1's interaction with other proteins in signaling pathways or structural networks. Its specificity and reliability are critical for validating experimental models, such as genetically modified animals or in vitro cardiomyocyte systems, advancing our understanding of heart diseases and therapeutic strategies.
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