| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/50-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HPTP; PTPD; HPTPD; HPTPDELTA; RPTPDELTA |
| Entrez GeneID | 5789 |
| clone | 5H5D7 |
| WB Predicted band size | 214.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PTPRD (AA: extra 1077-1265) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于Peroxiredoxin 3(PRDX3)抗体的3篇参考文献示例，包含文献名称、作者及摘要概括：
1. **文献名称**：*"Mitochondrial Peroxiredoxin III is a Target of the c-Jun N-terminal Kinase Pathway and Protects Cells Against Oxidative Stress"*
**作者**：Chae HZ et al.
**摘要**：本研究揭示了PRDX3在线粒体抗氧化防御中的作用，通过抗体检测发现其表达受JNK信号通路调控。实验表明，PRDX3敲低会增强氧化应激诱导的细胞凋亡，提示其在维持线粒体氧化还原平衡中的关键性。
2. **文献名称**：*"Peroxiredoxin III as a Biomarker for Hepatocellular Carcinoma: Immunohistochemical Analysis in Human Tissue"*
**作者**：Kim JH et al.
**摘要**：通过PRDX3抗体进行免疫组化分析，发现其在肝细胞癌(HCC)组织中显著高表达，且与患者预后不良相关。研究表明PRDX3可作为HCC的潜在诊断标志物和治疗靶点。
3. **文献名称**：*"Altered Expression of Peroxiredoxin III in Alzheimer's Disease Brains: Association with Mitochondrial Dysfunction"*
**作者**：Motta M et al.
**摘要**：利用PRDX3抗体检测阿尔茨海默病患者脑组织，发现其表达水平与线粒体功能损伤程度呈负相关。结果提示PRDX3可能通过调控氧化应激参与神经退行性病变的病理过程。
(注：以上文献标题和作者为示例性内容，实际引用时需以具体检索结果为准。)
Peroxiredoxin 3 (PRDX3), a member of the peroxiredoxin family of antioxidant enzymes, is primarily localized in mitochondria, where it plays a critical role in maintaining redox homeostasis. As a thioredoxin-dependent peroxidase, PRDX3 catalyzes the reduction of hydrogen peroxide (H₂O₂) and organic hydroperoxides, protecting mitochondrial components—including DNA, proteins, and lipids—from oxidative damage. Its function extends beyond antioxidant defense, influencing apoptosis, cell signaling, and mitochondrial metabolism. Dysregulation of PRDX3 has been implicated in various pathologies, including neurodegenerative disorders, cardiovascular diseases, and cancer, where oxidative stress is a contributing factor.
Antibodies targeting PRDX3 are essential tools for studying its expression, localization, and function in biological systems. These antibodies enable detection and quantification of PRDX3 in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Given the mitochondrial specificity of PRDX3. such antibodies are particularly valuable in research exploring mitochondrial dysfunction, aging, and diseases linked to oxidative stress. Additionally, PRDX3 antibodies are used to investigate its potential as a biomarker for cancer prognosis or therapeutic response, as altered PRDX3 levels correlate with tumor progression and drug resistance. Validation of antibody specificity, often through knockout controls or siRNA silencing, is crucial to ensure accurate experimental outcomes. Overall, PRDX3 antibodies provide critical insights into cellular redox mechanisms and their implications in health and disease.
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