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Rabbit Polyclonal Transglutaminase2 Antibody

  • 中文名： Transglutaminase 2抗体
  • 别    名： TGM2; Protein-glutamine gamma-glutamyltransferase 2; Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2
货号: IPDX23464
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTGM2; Protein-glutamine gamma-glutamyltransferase 2; Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2
Entrez GeneID7052
WB Predicted band sizeCalculated MW: 77 kDa; Observed MW: 77 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenA synthesized peptide derived from human TGM2
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于Transglutaminase 2(TG2)抗体的参考文献及其摘要概括：

1. **文献名称**: *"Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease"*

**作者**: Sollid, L.M., Jabri, B.

**摘要**: 该研究揭示了组织型转谷氨酰胺酶2(TG2)在乳糜泻中催化麦胶蛋白的脱酰胺作用，生成的修饰肽段可被肠道T细胞识别，解释了TG2自身抗体在此病中的产生机制。

2. **文献名称**: *"Transglutaminase 2 as a biomarker for celiac disease: A review"*

**作者**: Dieterich, W., et al.

**摘要**: 本文总结了TG2抗体作为乳糜泻血清学诊断标志物的临床应用，强调其在疾病筛查和监测中的高敏感性和特异性，并讨论了抗体与肠黏膜损伤的关联。

3. **文献名称**: *"Targeting transglutaminase 2 in fibrotic disease and cancer"*

**作者**: Piper, J.L., et al.

**摘要**: 研究探讨了TG2在纤维化和肿瘤微环境中的作用，提出利用TG2特异性抗体进行靶向治疗的潜力，包括抑制其酶活性和调节细胞外基质重塑的策略。

(注：以上文献信息为示例，实际引用时建议通过PubMed或学术数据库核对最新版本。)

背景信息

Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme belonging to the transglutaminase family, which catalyzes calcium-dependent post-translational protein modifications, including crosslinking, deamidation, and GTPase activity. It plays roles in diverse cellular processes such as apoptosis, extracellular matrix stabilization, and cell signaling. TG2 antibodies are immunological tools targeting this enzyme, widely used in research and diagnostics. In autoimmune disorders like celiac disease, TG2 autoantibodies are critical diagnostic markers. Specifically, IgA-class anti-TG2 antibodies are highly specific for celiac disease, where TG2 deamidates gluten peptides, triggering an immune response. These antibodies are detected via ELISA or immunofluorescence, aiding in disease diagnosis and monitoring. Additionally, TG2 antibodies are employed in cancer research, as TG2 overexpression is linked to tumor progression, metastasis, and drug resistance. Monoclonal antibodies against TG2 help study its role in extracellular matrix remodeling and cancer cell survival. Researchers also use TG2 inhibitors or antibodies to explore therapeutic strategies. However, commercial TG2 antibodies vary in specificity; some may cross-react with other transglutaminase isoforms, necessitating validation for accurate interpretation. Overall, TG2 antibodies are pivotal in understanding the enzyme's multifunctional roles in health and disease.

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