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Rabbit Polyclonal SP1 Antibody

  • 中文名： SP1抗体
  • 别    名： SP1; TSFP1; Transcription factor Sp1
货号: IPDX23459
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSP1; TSFP1; Transcription factor Sp1
Entrez GeneID6667
WB Predicted band sizeCalculated MW: 81 kDa; Observed MW: 90 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human SP1
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

1. **"Sp1 is involved in 5-fluorouracil resistance in colorectal cancer cells by regulating the PI3K/AKT signaling pathway"**

*作者：Li Y, et al.*

摘要：研究利用SP1抗体探讨了SP1转录因子在结直肠癌细胞对5-氟尿嘧啶耐药中的作用，发现SP1通过调控PI3K/AKT通路影响化疗敏感性。

2. **"SP1-mediated upregulation of lncRNA SNHG6 promotes non-small cell lung cancer progression"**

*作者：Wang H, et al.*

摘要：通过ChIP实验(使用SP1抗体)证实SP1结合SNHG6启动子区，促进非小细胞肺癌中长链非编码RNA表达，驱动肿瘤增殖和转移。

3. **"Sp1 regulates the expression of the BRCA1 gene in breast cancer cells"**

*作者：Kim J, et al.*

摘要：研究利用SP1抗体进行染色质免疫沉淀分析，揭示SP1通过直接结合BRCA1基因启动子调控其转录，影响乳腺癌细胞的DNA修复能力。

4. **"Sp1 as a potential biomarker for diabetic nephropathy progression"**

*作者：Zhang L, et al.*

摘要：通过免疫组化(SP1抗体染色)发现肾组织中SP1表达水平与糖尿病肾病炎症和纤维化程度相关，提示其作为疾病进展的生物标志物潜力。

背景信息

SP1 antibody targets Specificity Protein 1 (SP1), a transcription factor belonging to the SP/KLF family. Discovered in the 1980s, SP1 binds GC-rich promoter regions (GC-boxes) via three zinc finger domains, regulating genes involved in cell growth, differentiation, and apoptosis. It interacts with coactivators/corepressors (e.g., p300. HDACs) and modulates chromatin structure. SP1 is ubiquitously expressed but dysregulated in cancers (e.g., overexpression in tumors), neurodegenerative diseases, and viral infections (e.g., HPV, HIV). Its role in oncogenesis includes promoting cell proliferation (via cyclin D1. VEGF) and inhibiting apoptosis (via survivin). SP1 antibodies are essential tools in research—used in techniques like ChIP, Western blot, and immunofluorescence to study SP1-DNA/Protein interactions, expression patterns, and subcellular localization. Commercial SP1 antibodies (polyclonal/monoclonal) vary in specificity; validation via knockout controls is recommended. Dysregulation studies using these antibodies have informed therapeutic strategies targeting SP1 activity in cancer and inflammation.

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