| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | JAK1; JAK1A; JAK1B; Tyrosine-protein kinase JAK1; Janus kinase 1; JAK-1 |
| Entrez GeneID | 3716 |
| WB Predicted band size | Calculated MW: 133 kDa; Observed MW: 133 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from human JAK1 around the phosphorylation site of Tyr1022. AA range:988-1037 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于IKKβ抗体的参考文献示例(内容为模拟生成，仅供参考)：
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1. **文献名称**: *Targeting IKKβ Activity via Monoclonal Antibody Attenuates Inflammation in Sepsis Models*
**作者**: Zhang L, et al.
**摘要**: 该研究开发了一种针对IKKβ的单克隆抗体，验证其在脓毒症小鼠模型中抑制NF-κB通路的能力。实验表明，该抗体能显著减少促炎因子(如TNF-α、IL-6)释放，改善器官损伤。
2. **文献名称**: *IKKβ-Specific Antibody Inhibits Osteoclastogenesis and Alleviates Rheumatoid Arthritis*
**作者**: Tanaka M, et al.
**摘要**: 研究利用IKKβ抗体阻断破骨细胞分化中的NF-κB活化，发现其可抑制RANKL诱导的骨吸收，并在类风湿性关节炎动物模型中减轻关节破坏和炎症反应。
3. **文献名称**: *A Novel Phospho-Specific IKKβ Antibody Reveals Kinase Activation Dynamics in Cancer Cells*
**作者**: Chen H, et al.
**摘要**: 该文献报道了一种磷酸化特异性IKKβ抗体，用于检测IKKβ在肿瘤细胞中的激活状态。通过Western blot和免疫荧光，揭示了IKKβ在DNA损伤反应中的时空动态变化。
4. **文献名称**: *Therapeutic Potential of Humanized IKKβ Antibody in Chronic Inflammatory Diseases*
**作者**: Gupta S, et al.
**摘要**: 研究通过人源化IKKβ抗体在结肠炎和银屑病模型中的实验，证明其可选择性抑制炎症信号，减少免疫细胞浸润，且未显著影响天然免疫防御功能。
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**注意**：以上文献信息为示例，非真实存在。实际引用时建议通过PubMed、Web of Science等平台检索真实文献(关键词：IKKβ antibody、IKBKB inhibitor)。
The IKK beta (IkB kinase beta) antibody is a crucial tool in studying the NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling pathway, a central regulator of immune responses, inflammation, and cell survival. IKK beta, encoded by the IKBKB gene, is a catalytic subunit of the IKK complex (IKKα, IKKβ, and NEMO/IKKγ) that phosphorylates the inhibitory IkB proteins, leading to their degradation and subsequent activation of NF-κB transcription factors. Dysregulation of IKK beta is linked to chronic inflammation, autoimmune diseases, and cancer, making it a key therapeutic target.
IKK beta antibodies are widely used in research to detect protein expression, phosphorylation status (e.g., Ser177/181 for activation), and interactions within signaling pathways. They enable techniques like Western blotting, immunohistochemistry, and immunoprecipitation to study IKK beta's role in cellular responses to cytokines, pathogens, or stress signals. Specific antibodies can distinguish between inactive and activated forms, aiding in mechanistic studies of NF-κB activation. These antibodies are also vital in preclinical studies evaluating IKK beta inhibitors for diseases such as rheumatoid arthritis, inflammatory bowel disease, and certain cancers. Validated IKK beta antibodies ensure specificity across species (human, mouse, rat) and sample types, supporting translational research in immunology and oncology.
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