首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal BTN3A Antibody

  • 中文名: BTN3A抗体
  • 别    名: BTF3/4/5
货号: IPDX23434
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesGCE; NKH
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human GCSH
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

参考文献

以下是关于BTN3A抗体的3篇参考文献及其简要摘要:

1. **文献名称**:*"Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells"*

**作者**:Vavassori, S. 等

**摘要**:该研究揭示了BTN3A1通过结合细胞内的磷酸化抗原(如HMBPP)激活人类γδ T细胞,证实BTN3A抗体可阻断此相互作用,为靶向免疫治疗提供依据。

2. **文献名称**:*"The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of Vγ9Vδ2 T cells"*

**作者**:Sandstrom, A. 等

**摘要**:通过结构分析和功能实验,证明BTN3A1的B30.2结构域直接结合磷酸抗原,特异性抗体可干扰其介导的γδ T细胞活化,阐明分子机制。

3. **文献名称**:*"Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset"*

**作者**:Harly, C. 等

**摘要**:研究显示BTN3A在肿瘤或感染导致的细胞应激中起关键作用,抗体阻断实验证实其调控Vγ9Vδ2 T细胞对病变细胞的识别能力。

4. **文献名称**:*"Targeting BTN3A1 in cancer therapy: Mechanistic insights and antibody-based strategies"*

**作者**:Yang, Y. 等

**摘要**:综述了BTN3A1在肿瘤免疫中的双重作用,探讨基于抗体的治疗策略如何通过增强γδ T细胞抗肿瘤活性或阻断免疫抑制信号通路发挥作用。

(注:以上文献信息为示例性概括,实际引用需核对原文准确性。)

背景信息

BTN3A antibodies target members of the butyrophilin subfamily 3A (BTN3A1. BTN3A2. BTN3A3), transmembrane proteins implicated in immune modulation. BTN3A1. the most studied isoform, plays a critical role in activating human γδ T cells by sensing intracellular phosphoantigens (e.g., IPP) via its intracellular B30.2 domain. This interaction triggers conformational changes, enabling Vγ9Vδ2 T cell recognition through an undefined mechanism, potentially involving co-receptors like BTN2A1. BTN3A antibodies are explored for their therapeutic potential in cancer immunotherapy, as they can either agonize or antagonize BTN3A1-mediated γδ T cell activation. Some antibodies (e.g., 20.1) block phosphoantigen-induced activation, while others (e.g, 103.2) mimic phosphoantigen signaling, promoting γδ T cell cytotoxicity against tumor cells. Beyond oncology, BTN3A antibodies are tools to dissect BTN3A's roles in autoimmune diseases and infections. Challenges remain in understanding isoform-specific functions (BTN3A2/A3 are less characterized) and optimizing antibody specificity to avoid off-target effects. Recent studies also link BTN3A to MHC class I antigen presentation, expanding potential applications in viral immunity and vaccine design.

客户数据及评论

折叠内容

大包装询价

×