| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IGLC1 |
| Entrez GeneID | 3537 |
| WB Predicted band size | Calculated MW: 11 kDa; Observed MW: 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length native protein (purified) corresponding to Human Human IgG Lambda Light Chain. Human IgG purified from Human plasma. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
+ +
以下是关于人类lambda轻链抗体的3篇代表性文献(注：以下为模拟示例，实际文献需通过数据库检索获取)：
---
1. **文献名称**：*Structural analysis of human lambda light chain antibodies in B-cell malignancies*
**作者**：Smith, J. et al.
**摘要**：本研究通过X射线晶体学解析了人类lambda轻链抗体的高分辨率结构，揭示了其与κ轻链的结构差异，并探讨了在B细胞恶性肿瘤中lambda轻链异常表达的分子机制。
---
2. **文献名称**：*Lambda light chain dominance in autoimmune disorders: A serological study*
**作者**：Chen, L. & Wang, H.
**摘要**：通过ELISA和免疫印迹分析，发现系统性红斑狼疮患者血清中lambda轻链抗体比例显著升高，提示其可能作为自身免疫疾病的潜在生物标志物。
---
3. **文献名称**：*Novel lambda light chain-based bispecific antibodies for cancer immunotherapy*
**作者**：Rodriguez, M. et al.
**摘要**：开发了一种基于lambda轻链的双特异性抗体，可同时靶向CD3和肿瘤抗原，在体外和小鼠模型中展示了增强的T细胞介导的肿瘤杀伤活性。
---
**建议**：可通过PubMed或Google Scholar搜索关键词“human lambda light chain antibody”、“lambda light chain structure/function”获取更多文献，注意筛选近5年内的研究以追踪最新进展。
Human lambda (λ) light chain antibodies are integral components of immunoglobulin molecules, which play a central role in adaptive immunity. Antibodies consist of two heavy chains and two light chains, with light chains existing as either lambda or kappa (κ) isotypes. Lambda light chains, encoded by the IGLC gene cluster on chromosome 22. pair with heavy chains to form the antigen-binding site via their variable (VL) domains, while their constant (CL) domains contribute to structural stability. In humans, approximately 40% of antibodies contain lambda light chains, with kappa chains being more prevalent (60%).
Lambda light chains are expressed during B-cell development and are critical for antibody diversity. Their production is tightly regulated, and abnormal levels can indicate pathological conditions. For instance, monoclonal lambda light chain overproduction is a hallmark of plasma cell disorders like multiple myeloma or monoclonal gammopathy. Antibodies specific to human lambda light chains are widely used in research and diagnostics to detect and quantify these proteins in clinical samples (e.g., serum, urine). They help identify clonal B-cell populations, assess light chain restriction in lymphoproliferative diseases, and monitor treatment response.
In research, anti-lambda antibodies are employed in techniques like Western blotting, immunohistochemistry, and flow cytometry to study B-cell biology, antibody engineering, and disease mechanisms. Their specificity enables differentiation between lambda and kappa light chains, aiding in precise immunological analyses.
×
