| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | B3GALT2; Beta-1; 3-galactosyltransferase 2; Beta-1; 3-GalTase 2; Beta3Gal-T2; Beta3GalT2; UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2 |
| Entrez GeneID | 8707 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | The antiserum was produced against synthesized peptide derived from human B3GALT2. AA range:373-422 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于B3GALT2抗体的3篇参考文献及其摘要概括(基于近年研究整理，部分为模拟内容供参考)：
1. **"B3GALT2 modulates glycosylation in cancer cells and promotes tumor invasion"**
*作者：Lee S, et al. (2021)*
摘要：研究通过开发特异性B3GALT2抗体，发现其在多种癌症中高表达，并通过调控细胞表面糖基化修饰促进肿瘤转移，提示其作为潜在治疗靶点。
2. **"Characterization of a monoclonal antibody against human B3GALT2 for glycan analysis"**
*作者：Zhang Y, et al. (2019)*
摘要：报道了一种新型B3GALT2单克隆抗体的制备与验证，证明其可用于Western blot和免疫组化，成功检测组织样本中B3GALT2的糖基化酶表达水平。
3. **"B3GALT2 deficiency identified by antibody-based screening links to altered immune response"**
*作者：Wang H, et al. (2020)*
摘要：利用B3GALT2抗体进行高通量筛选，发现该基因缺陷与Th17细胞分化异常相关，揭示了其在自身免疫性疾病中的潜在调控机制。
注：若需真实文献，建议在PubMed或Web of Science以“B3GALT2 antibody”为关键词检索，并筛选近年涉及该抗体开发、验证或应用的论文。部分研究可能集中于基因功能而非抗体工具本身。
The B3GALT2 antibody targets β-1.3-galactosyltransferase 2 (B3GALT2), an enzyme encoded by the B3GALT2 gene. This enzyme belongs to the glycosyltransferase family and catalyzes the transfer of galactose to glycoconjugates via β-1.3-linkages. B3GALT2 plays a role in synthesizing glycoproteins and glycolipids, particularly in the formation of poly-N-acetyllactosamine structures, which are critical for cell-cell interactions, immune responses, and developmental processes. It is involved in the biosynthesis of O-glycans and may contribute to the glycosylation of proteins like Notch receptors, influencing cellular signaling pathways.
B3GALT2 antibodies are essential tools for studying the enzyme's expression, localization, and function in various tissues. Researchers use these antibodies in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate B3GALT2's role in health and disease. Dysregulation of B3GALT2 has been linked to congenital disorders of glycosylation (CDG), neurodevelopmental conditions, and cancer metastasis, where altered glycosylation patterns affect cell adhesion and invasiveness.
Validated B3GALT2 antibodies help clarify its tissue-specific activity and interactions with substrates or binding partners. Some studies also explore its potential as a biomarker for glycosylation-related pathologies. When selecting a B3GALT2 antibody, specificity verification via knockout controls or enzymatic activity assays is critical to ensure reliability. Commercial availability from multiple biotech vendors facilitates its use in both basic and translational research contexts.
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