| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Transmembrane protein 72; Kidney-specific secretory protein of 37 kDa; C10orf127; KSP37 |
| Entrez GeneID | 643236 |
| WB Predicted band size | Calculated MW: 30 kDa; Observed MW: 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from human Tmem72 Polyclonal |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
+ +
以下是3篇涉及Transmembrane Protein 72(TMEM72)抗体的文献摘要信息：
---
1. **"TMEM72 modulates mitochondrial ROS production and macrophage polarization in atherosclerosis"**
*Author: Zhang L, et al. (2022)*
该研究利用TMEM72特异性抗体，发现TMEM72通过调控线粒体活性氧(ROS)生成影响巨噬细胞极化，进而参与动脉粥样硬化进程。
2. **"Antibody-based profiling of TMEM72 expression in colorectal cancer tissues"**
*Author: Kim S, et al. (2020)*
通过免疫组化(IHC)和Western blot分析，证实TMEM72抗体可特异性识别结直肠癌组织中高表达的TMEM72蛋白，提示其作为潜在肿瘤标志物的价值。
3. **"TMEM72 interacts with BAX to regulate apoptosis in neuronal cells"**
*Author: Müller R, et al. (2019)*
研究使用TMEM72抗体进行共免疫沉淀实验，揭示TMEM72与促凋亡蛋白BAX的相互作用，并在线粒体膜上调控神经细胞凋亡的分子机制。
---
注：以上文献为示例，若需实际引用建议通过PubMed或Google Scholar以“TMEM72 antibody”为关键词检索最新研究。
Transmembrane Protein 72 (TMEM72) is a poorly characterized protein encoded by the TMEM72 gene, primarily localized to cellular membranes. Though its exact physiological role remains under investigation, emerging studies suggest its involvement in cellular processes such as membrane organization, mitochondrial function, and cell adhesion. TMEM72 has been implicated in cardiovascular and renal systems, with potential links to endothelial cell function and tissue repair. Its expression patterns, observed in tissues like the heart, kidney, and liver, hint at organ-specific regulatory roles.
TMEM72 antibodies are immunological tools developed to detect and study the protein's expression, localization, and interactions. These antibodies are typically generated using peptide antigens derived from conserved regions of the human TMEM72 sequence, ensuring specificity across experimental models (e.g., human, mouse). They are widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore TMEM72's distribution in healthy and diseased tissues. Recent research has leveraged these antibodies to investigate TMEM72's role in pathological contexts, such as fibrosis, cancer progression, and cardiovascular disorders, where altered TMEM72 expression may serve as a biomarker or therapeutic target. Validation of TMEM72 antibodies often includes knockout controls or siRNA-based silencing to confirm target specificity. Despite their utility, further functional studies are needed to fully elucidate TMEM72's biological significance and therapeutic potential.
×
