| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Collagen alpha-1(XIII) chain (COLXIIIA1) |
| Entrez GeneID | 1305 |
| WB Predicted band size | Calculated MW: 70 kDa; Observed MW: 70 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from human COL13A1. at AA range: 41-90 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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1. **"Collagen XIII is required for neuromuscular synapse regeneration and functional recovery after peripheral nerve injury"**
- Author: S. Ylikallio et al.
- 摘要：研究利用Col13a1抗体分析小鼠神经损伤后神经肌肉接头再生，发现Collagen XIII α1在突触再生和功能恢复中的关键作用。
2. **"Collagen XIII derived ectodomain regulates bone angiogenesis and osteoblast-osteoclast crosstalk"**
- Author: M. Välimäki et al.
- 摘要：通过Col13a1抗体检测发现，Collagen XIII α1的胞外结构域调控骨血管生成及成骨细胞-破骨细胞相互作用，影响骨稳态。
3. **"Collagen XIII is a transmembrane protein involved in cell-matrix interactions"**
- Author: R. Härönen et al.
- 摘要：利用特异性抗体证实Collagen XIII α1为跨膜蛋白，参与细胞黏附与基质重塑，影响皮肤和骨骼发育。
4. **"Altered expression of collagen XIII in corneal scarring and fibrosis"**
- Author: K. Tsubota et al.
- 摘要：通过免疫组化(Col13a1抗体)发现角膜瘢痕中Collagen XIII α1表达异常，提示其与纤维化病理过程相关。
(注：以上文献为示例，实际引用时需核对真实文献信息。)
Collagen XIII alpha 1 (COL13A1) is a transmembrane collagen encoded by the *COL13A1* gene, belonging to the non-fibrillar collagen family. Unlike classical collagens, it features a short collagenous domain flanked by non-collagenous regions, with an N-terminal intracellular domain and a C-terminal transmembrane domain. This structure enables its role in cell-matrix interactions, cell adhesion, and tissue organization. COL13A1 is expressed in various tissues, including skeletal muscle, skin, and epithelial cells, and is localized to cell membranes or extracellular matrices depending on proteolytic processing.
Antibodies targeting COL13A1 are essential tools for studying its expression, localization, and function. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to investigate its involvement in developmental processes, tissue repair, and disease mechanisms. Research highlights its role in neuromuscular junction formation, where COL13A1 regulates acetylcholinesterase anchoring, and in cancer progression, where aberrant expression correlates with tumor invasion and metastasis. Mutations in *COL13A1* are linked to congenital myasthenic syndromes and epithelial-related disorders.
These antibodies aid in elucidating COL13A1's dual roles as a structural component and signaling mediator, offering insights into therapeutic targeting for related pathologies. Specificity validation (e.g., knockout controls) is critical due to potential cross-reactivity with other collagens.
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