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Rabbit Polyclonal GCM2 Antibody

  • 中文名: GCM2抗体
  • 别    名: Chorion-specific transcription factor GCMb (hGCMb; GCM motif protein 2; Glial cells missing homolog 2)
货号: IPDX23420
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesChorion-specific transcription factor GCMb (hGCMb; GCM motif protein 2; Glial cells missing homolog 2)
Entrez GeneID9247
WB Predicted band sizeCalculated MW: 57 kDa; Observed MW: 57 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenSynthesized peptide derived from human GCM2. at AA range: 21-70
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于GCM2抗体的模拟参考文献示例(内容为虚构,仅供格式参考):

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1. **文献名称**: *Autoantibodies Against GCM2 in Autoimmune Hypoparathyroidism*

**作者**: Yamamoto K, et al.

**摘要**: 该研究首次报道在特发性甲状旁腺功能减退症患者血清中检测到抗GCM2自身抗体,提示GCM2可能作为自身免疫攻击的靶点,并探讨了抗体水平与疾病严重程度的相关性。

2. **文献名称**: *GCM2 as a Key Regulator of Parathyroid Development: Implications for Antibody Detection*

**作者**: Smith J, Patel R.

**摘要**: 通过免疫组化和Western blot分析,证实GCM2在甲状旁腺细胞核中高表达,并开发了一种高特异性ELISA方法用于检测抗GCM2抗体,为临床诊断提供新工具。

3. **文献名称**: *Clinical Significance of GCM2 Antibodies in Chronic Kidney Disease Patients*

**作者**: Chen L, et al.

**摘要**: 研究纳入200例慢性肾病继发甲状旁腺功能亢进患者,发现约12%存在抗GCM2抗体阳性,提示此类抗体可能干扰继发性甲状旁腺增生的调控机制。

4. **文献名称**: *GCM2 Antibody-Associated Parathyroiditis: A Case Series Study*

**作者**: García M, et al.

**摘要**: 报道3例罕见抗GCM2抗体阳性甲状旁腺炎病例,临床表现为低钙血症和甲状旁腺萎缩,病理显示淋巴细胞浸润,支持抗体介导的自身免疫损伤假说。

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注:以上文献为示例性质,实际研究中请通过学术数据库核实真实文献。

背景信息

GCM2 (Glial Cells Missing Homolog 2) is a transcription factor belonging to the GCM protein family, characterized by a conserved DNA-binding domain known as the GCM motif. Initially identified in *Drosophila* for its role in glial cell development, mammalian GCM2 is primarily expressed in the parathyroid glands, where it regulates the development and function of parathyroid cells. It directly controls the transcription of parathyroid hormone (PTH), a key regulator of calcium homeostasis. Dysregulation of GCM2 is linked to parathyroid disorders, such as hyperparathyroidism or hypoparathyroidism, and mutations in the *GCM2* gene have been associated with familial isolated hypoparathyroidism.

GCM2 antibodies are immunological tools used to detect and study the expression, localization, and function of the GCM2 protein in research and diagnostic contexts. In research, these antibodies aid in investigating parathyroid gland biology, PTH secretion mechanisms, and the molecular basis of calcium-related pathologies. Clinically, they may assist in diagnosing parathyroid tumors or differentiating parathyroid tissue from other tissues in pathological samples. GCM2 antibodies are typically validated for techniques like immunohistochemistry, Western blotting, and immunofluorescence. Recent studies also explore GCM2's potential role in cancers, including its ectopic expression in certain malignancies, broadening its relevance in both endocrine and oncological research.

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