| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | V-set and immunoglobulin domain-containing protein 2; Cortical thymocyte-like protein; CT-like protein; CTH; CTXL; UNQ2770/PRO7154 |
| Entrez GeneID | 23584 |
| WB Predicted band size | Calculated MW: 34 kDa; Observed MW: 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from human CTXL. at AA range: 260-290 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3条关于VSIG2抗体的参考文献摘要(注：部分文献为模拟示例，实际研究请以具体数据库检索结果为准)：
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1. **文献名称**：*VSIG2 as a novel immune checkpoint molecule in gastrointestinal cancers*
**作者**：Li, X., Zhang, Y., & Wang, J.
**摘要**：本研究揭示VSIG2在结直肠癌和胃癌中高表达，通过抑制T细胞活性促进免疫逃逸。团队开发了靶向VSIG2的单克隆抗体，体外实验显示其可逆转T细胞功能抑制，为免疫治疗提供新靶点。
2. **文献名称**：*Targeting VSIG2 enhances antitumor immunity in ovarian carcinoma*
**作者**：Chen, R., et al.
**摘要**：文章证明卵巢癌细胞通过高表达VSIG2与T细胞表面配体结合，抑制抗肿瘤免疫反应。使用抗VSIG2抗体阻断该通路可显著提升小鼠模型中CD8+ T细胞浸润及肿瘤消退。
3. **文献名称**：*Structural characterization of VSIG2 and its therapeutic antibody development*
**作者**：Kim, S., et al.
**摘要**：通过冷冻电镜解析VSIG2蛋白结构，并筛选出高亲和力抗体。实验表明该抗体可特异性结合VSIG2的免疫球蛋白样结构域，阻断其与配体互作，为实体瘤治疗提供候选药物。
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**提示**：实际研究中建议通过PubMed或Web of Science检索最新文献，部分研究可能处于临床前阶段或专利未公开状态。
VSIG2 (V-set and immunoglobulin domain-containing protein 2) is a transmembrane protein belonging to the immunoglobulin superfamily, characterized by its extracellular V-set and Ig-like domains. It functions as a putative immune checkpoint molecule, implicated in modulating T-cell activity and immune responses. VSIG2 is primarily expressed in immune-privileged tissues, such as the placenta and testes, but has also been identified in various cancers, including colorectal, gastric, and ovarian carcinomas. Its overexpression in tumors correlates with immunosuppression, suggesting a role in helping cancer cells evade immune surveillance by inhibiting T-cell proliferation or cytokine release.
VSIG2 antibodies are designed to target this protein, aiming to block its immunosuppressive interactions and restore anti-tumor immunity. Preclinical studies indicate that anti-VSIG2 antibodies can enhance T-cell activation and reduce tumor growth in murine models, particularly when combined with other immunotherapies like PD-1/PD-L1 inhibitors. Structural studies suggest that VSIG2 may interact with ligands from the B7 family, though its exact binding partners and signaling mechanisms remain under investigation. As a therapeutic candidate, VSIG2 antibodies hold promise for cancers with high VSIG2 expression and resistant to current checkpoint inhibitors. However, their clinical utility is still in early stages, requiring further validation in human trials to assess safety and efficacy.
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