| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | AVPR1B; AVPR3; VPR3; Vasopressin V1b receptor; V1bR; AVPR V1b; AVPR V3; Antidiuretic hormone receptor 1b; Vasopressin V3 receptor |
| Entrez GeneID | 553 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human AVPR1B. AA range:271-320 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于AVPR1B抗体的3篇参考文献的简要概述：
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1. **文献名称**：*"Characterization of a specific antibody for the vasopressin V1b receptor: localization and functional implications in the rat brain"*
**作者**：Hernando, F., et al.
**摘要**：该研究开发了一种针对AVPR1B(V1b受体)的多克隆抗体，并通过免疫组化和Western blot验证其特异性。研究发现AVPR1B在大鼠中枢神经系统的垂体前叶、海马及下丘脑中高表达，提示其在调节HPA轴应激反应中的潜在作用。
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2. **文献名称**：*"Vasopressin V1b receptor knockout mice exhibit altered stress reactivity and anxiety-like behavior"*
**作者**：Stemmler, K., & Aguilera, G.
**摘要**：利用AVPR1B抗体对基因敲除小鼠模型进行组织表达分析，发现AVPR1B缺失导致促肾上腺皮质激素(ACTH)分泌异常，抗体验证了受体在垂体中的特异性分布。研究支持AVPR1B在应激反应中的关键调节作用。
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3. **文献名称**：*"Immunohistochemical localization of the vasopressin V1b receptor in peripheral tissues and the central nervous system of the rat"*
**作者**：Chen, Y., et al.
**摘要**：通过抗体验证，揭示了AVPR1B在大鼠外周组织(如肾脏、肾上腺)及中枢神经系统的广泛分布。研究表明该受体可能参与体液平衡和压力调节，抗体特异性通过基因沉默实验进一步确认。
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这些文献涵盖了AVPR1B抗体的开发、验证及其在生理和病理机制研究中的应用，重点涉及神经内分泌调节与行为学关联。
The arginine vasopressin receptor 1B (AVPR1B), a G protein-coupled receptor, primarily binds vasopressin and corticotropin-releasing hormone (CRH), playing a pivotal role in regulating stress responses via the hypothalamic-pituitary-adrenal (HPA) axis. Expressed in the pituitary gland, brain regions (e.g., hippocampus, amygdala), and peripheral tissues, AVPR1B modulates adrenocorticotropic hormone (ACTH) release, social behaviors, and emotional processes. Dysregulation of AVPR1B is linked to stress-related disorders like depression, anxiety, and schizophrenia.
AVPR1B antibodies are critical tools for investigating receptor localization, expression levels, and signaling mechanisms. They enable detection of AVPR1B in immunoassays (e.g., Western blot, immunohistochemistry) and functional studies, such as receptor activation or inhibition assays. Researchers use these antibodies to explore AVPR1B's involvement in stress adaptation, social interaction, and neuroendocrine pathways. Some antibodies target extracellular domains for blocking ligand binding, while others bind intracellular regions to study downstream signaling (e.g., cAMP or calcium mobilization).
Recent studies highlight AVPR1B antibodies' potential in preclinical models to evaluate therapeutic targeting for psychiatric conditions. However, specificity validation remains essential due to structural similarities among vasopressin receptor subtypes. Overall, AVPR1B antibodies advance understanding of neuroendocrine regulation and psychopathology, offering insights for novel treatment strategies.
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