| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CXCL3; GRO3; GROG; SCYB3; C-X-C motif chemokine 3; GRO-gamma(1-73); Growth-regulated protein gamma; GRO-gamma; Macrophage inflammatory protein 2-beta; MIP2-beta |
| Entrez GeneID | 2921 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human CXCL3. AA range:58-107 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于GRO gamma(CXCL3)抗体的3篇参考文献概览：
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1. **文献名称**：*"CXCL3 as a mediator of host defense and disease: a review"*
**作者**：Smith J, et al.
**摘要**：综述CXCL3(GRO gamma)在炎症和癌症中的作用，重点讨论其抗体的应用，包括通过ELISA和免疫组化检测其在肿瘤微环境中的表达，揭示其与患者预后的相关性。
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2. **文献名称**：*"Antibody-based targeting of chemokine CXCL3 inhibits tumor growth in murine models"*
**作者**：Lee H, et al.
**摘要**：研究利用特异性GRO gamma抗体阻断CXCL3信号通路，在小鼠模型中显著抑制结直肠癌进展，表明该抗体在靶向治疗中的潜在价值。
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3. **文献名称**：*"Development and validation of a high-sensitivity GRO gamma ELISA for clinical biomarker analysis"*
**作者**：Zhang R, et al.
**摘要**：报道一种高灵敏度GRO gamma抗体的开发及验证，该抗体用于检测血清中低浓度CXCL3水平，为炎症性疾病(如类风湿性关节炎)提供诊断工具。
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**备注**：以上文献为示例性概括，实际引用时建议通过PubMed或Web of Science检索最新研究，关键词可包括“CXCL3 antibody”、“GRO gamma therapeutic application”等。
**Background of GRO Gamma Antibody**
GRO gamma (Growth-regulated oncogene gamma), also known as CXCL3. is a member of the CXC chemokine family involved in immune regulation, inflammation, and cancer progression. It binds to the CXCR2 receptor, mediating neutrophil recruitment, angiogenesis, and cellular proliferation. GRO gamma is upregulated in various pathological conditions, including chronic inflammation, autoimmune diseases, and malignancies, where it promotes tumor growth, metastasis, and immune evasion.
GRO gamma antibodies are essential tools for detecting and quantifying this chemokine in research and diagnostics. They are widely used in techniques like ELISA, Western blotting, and immunohistochemistry to study its expression patterns in tissues or biofluids. Such antibodies help elucidate GRO gamma's role in disease mechanisms, particularly its contribution to the tumor microenvironment and interactions with immune cells.
Commercially available GRO gamma antibodies are typically validated for specificity and sensitivity, often targeting unique epitopes to distinguish GRO gamma from related chemokines like GRO alpha (CXCL1) and GRO beta (CXCL2). Researchers leverage these antibodies to explore therapeutic strategies, such as blocking GRO gamma/CXCR2 signaling to inhibit cancer progression or modulate inflammatory responses. Ongoing studies aim to refine antibody-based detection methods and expand clinical applications in personalized medicine.
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