| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CACTIN C19orf29 |
| Entrez GeneID | 58509 |
| WB Predicted band size | Calculated MW: 89 kDa; Observed MW: 95 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human CACTIN. AA range:141-190 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
+ +
以下是关于Cactin抗体的3篇代表性文献示例，包含文献名称、作者及摘要概括：
---
1. **文献名称**：*"Cactin regulates Toll-like receptor signaling through interaction with MyD88"*
**作者**：Li, X., et al.
**摘要**：该研究利用特异性Cactin抗体进行免疫共沉淀和Western blot分析，发现Cactin通过与接头蛋白MyD88相互作用，负向调控TLR/NF-κB信号通路，影响先天免疫反应。
---
2. **文献名称**：*"Cactin modulates spliceosome assembly and mRNA splicing in human cells"*
**作者**：Smith, J., & Wang, Y.
**摘要**：通过Cactin抗体的免疫荧光和RNA干扰实验，揭示了Cactin在剪接体组装中的关键作用，并证明其缺失导致mRNA剪接异常及细胞周期停滞。
---
3. **文献名称**：*"Functional characterization of Cactin in Drosophila immunity using antibody-based knockdown approaches"*
**作者**：Garcia, M., et al.
**摘要**：研究通过抗体制备和体内敲低技术，证明果蝇Cactin负调控抗菌肽表达，影响宿主对细菌感染的防御能力，提示其保守的免疫调节功能。
---
**备注**：以上文献为示例性质，实际研究可能需通过学术数据库(如PubMed、Google Scholar)检索具体论文。若需全文链接或更详细内容，建议结合关键词“Cactin antibody”或“Cactin immune function”进一步筛选。
Cactin is a highly conserved, ubiquitously expressed protein found in eukaryotes, initially identified through genetic studies in *Caenorhabditis elegans* and later characterized in mammals. It plays a multifaceted role in cellular processes, particularly in immune signaling pathways and developmental regulation. Structurally, Cactin contains a unique N-terminal domain and multiple leucine-rich repeats, suggesting involvement in protein-protein interactions. Research highlights its critical function as a negative regulator of the Toll-like receptor (TLR) and NF-κB signaling pathways, where it modulates inflammatory responses by inhibiting excessive activation of immune receptors. Dysregulation of Cactin has been linked to autoimmune disorders and chronic inflammation.
Cactin antibodies are essential tools for studying its expression, localization, and mechanistic roles. They enable detection via techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding investigations into its interaction partners and regulatory networks. Recent studies also implicate Cactin in cell cycle control and apoptosis, expanding its relevance in cancer biology. Commercial and custom-generated antibodies target specific epitopes, with validation emphasizing specificity across species (e.g., human, mouse). Despite its emerging significance, Cactin's full functional spectrum remains under exploration, necessitating further research to unravel its therapeutic potential in immune-related diseases and beyond.
×
