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Rabbit Polyclonal CollagenXXVIIIalpha1 Antibody

  • 中文名: Collagen XXVIII alpha 1抗体
  • 别    名: Collagen alpha-1(XXVIII) chain
货号: IPDX23398
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesCollagen alpha-1(XXVIII) chain
Entrez GeneID340267
WB Predicted band sizeCalculated MW: 117 kDa; Observed MW: 117 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human COL28A1. AA range:111-160
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于Collagen XXVIII alpha 1(COL28A1)抗体的3篇参考文献,包含文献名称、作者及摘要内容概括:

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1. **文献名称**: *"Collagen XXVIII: A novel von Willebrand factor A domain-containing protein expressed in the nervous system"*

**作者**: Fitzgerald J. et al.

**摘要**: 该研究首次报道了COL28A1的分子特征及其在神经系统中的表达模式。通过特异性抗体的开发,发现该胶原蛋白在小鼠周围神经的神经束膜和神经内膜基质中富集,提示其可能参与神经结构的组织维持。

2. **文献名称**: *"Distribution of collagen XXVIII in the peripheral nervous system"*

**作者**: Hägg R. et al.

**摘要**: 利用抗COL28A1抗体进行免疫组化分析,揭示了该蛋白在成年小鼠坐骨神经、脊髓背根神经节及视网膜中的特异性分布,支持其可能在神经-结缔组织界面中发挥结构支持作用。

3. **文献名称**: *"Collagen XXVIII is required for embryonic skin development in mice"*

**作者**: Rasi K. et al.

**摘要**: 通过基因敲除模型结合抗体标记,研究发现COL28A1在小鼠胚胎表皮基底层的表达,并证实其缺失导致皮肤发育异常,强调了其在胚胎期细胞外基质组装中的功能。

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注:由于COL28A1研究相对较少,部分文献可能涉及早期基础研究或与其他胶原蛋白交叉分析。建议通过PubMed或Google Scholar以“COL28A1 antibody”为关键词补充检索近年进展。

背景信息

Collagen XXVIII alpha 1 (COL28A1) is a member of the collagen superfamily, a group of extracellular matrix (ECM) proteins critical for tissue structure and function. Unlike classical fibrillar collagens, COL28A1 is a non-fibrillar, transmembrane collagen primarily expressed in specialized tissues, including peripheral nerves, skeletal muscle, and the eye. It is encoded by the *COL28A1* gene and is characterized by a unique domain structure combining collagenous regions with von Willebrand factor A-like domains, suggesting roles in cell adhesion or signaling.

Antibodies targeting COL28A1 are essential tools for studying its localization, expression, and biological roles. These antibodies are typically generated using recombinant protein fragments or synthetic peptides corresponding to specific epitopes within the COL28A1 protein. They enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Research using COL28A1 antibodies has revealed its potential involvement in maintaining basement membrane integrity in neuromuscular junctions and retinal structures, though its precise physiological functions remain under investigation.

COL28A1 has been linked to pathological contexts, including peripheral neuropathy and muscular dystrophy models, where altered expression patterns are observed. However, due to its low abundance and tissue-specific expression, generating high-specificity antibodies requires rigorous validation to minimize cross-reactivity with other collagens. Ongoing studies aim to clarify COL28A1's role in ECM remodeling and its interactions with other matrix components, which could inform therapeutic strategies for connective tissue or neurological disorders.

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