| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | PIK3C2G; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; PI3K-C2-gamma; PtdIns-3-kinase C2 subunit gamma; Phosphoinositide 3-kinase-C2-gamma |
| Entrez GeneID | 5288 |
| WB Predicted band size | Calculated MW: 166 kDa; Observed MW: 160 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the N-terminal region of human PI 3-Kinase C2γ. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于PI3K-C2γ抗体的参考文献示例(内容为示例性概括，具体文献需根据实际检索调整)：
1. **文献名称**: *Structural insights into the regulation of PI3K-C2γ enzyme activity*
**作者**: Deng L, et al.
**摘要**: 本研究通过X射线晶体学解析了PI3K-C2γ的催化结构域结构，并利用特异性抗体证实其在细胞中通过C2结构域与膜结合，调控脂质信号传导。
2. **文献名称**: *PI3K-C2γ modulates endosomal trafficking and cell migration*
**作者**: Smith JR, et al.
**摘要**: 通过免疫沉淀和抗体介导的蛋白敲低实验，发现PI3K-C2γ通过生成PI(3)P调控内体成熟，影响细胞迁移和肿瘤转移。
3. **文献名称**: *PI3K-C2γ deficiency links metabolic dysfunction to obesity*
**作者**: Chen X, et al.
**摘要**: 使用抗体检测发现，PI3K-C2γ在小鼠脂肪组织中高表达，其缺失导致胰岛素信号通路异常，促进肥胖和代谢综合征。
4. **文献名称**: *Antibody-based targeting of PI3K-C2γ in cancer therapy*
**作者**: Gupta S, et al.
**摘要**: 开发了针对PI3K-C2γ胞内结构域的单克隆抗体，证明其可抑制肿瘤血管生成，为实体瘤治疗提供新策略。
(注：以上为模拟内容，实际文献需通过PubMed/Google Scholar检索确认。)
The PI3K-C2γ (Phosphoinositide 3-Kinase Class 2 Gamma) antibody is a research tool used to study the PI3K-C2γ isoform, a member of the class II phosphatidylinositol 3-kinase (PI3K) family. PI3K-C2γ, encoded by the *PIK3C2G* gene, is a lipid kinase that phosphorylates phosphatidylinositol (PI) and phosphatidylinositol-4-phosphate (PI4P) to generate phosphatidylinositol-3-phosphate (PI3P) and phosphatidylinositol-3.4-bisphosphate (PI(3.4)P2), respectively. Unlike class I PI3Ks, which are primarily involved in acute signaling, class II PI3Ks like PI3K-C2γ regulate membrane trafficking, endocytosis, and metabolic processes. PI3K-C2γ contains a unique C-terminal C2 domain, which may mediate membrane binding and protein interactions.
Antibodies targeting PI3K-C2γ enable researchers to investigate its expression, subcellular localization (e.g., endosomal or plasma membrane associations), and roles in signaling pathways such as insulin signaling, angiogenesis, and autophagy. These antibodies are validated for techniques like Western blotting, immunofluorescence, and immunoprecipitation. Studies using PI3K-C2γ antibodies have linked its dysregulation to metabolic disorders, cancer progression, and cardiovascular diseases. Specificity validation (e.g., knockout controls) is critical due to structural similarities among PI3K isoforms. Overall, PI3K-C2γ antibodies are essential for elucidating its physiological and pathological functions in cellular homeostasis and disease mechanisms.
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