| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | TRMT11; C6orf75; MDS024; tRNA; guanine(10)-N2)-methyltransferase homolog; tRNA guanosine-2'-O-methyltransferase TRM11 homolog |
| Entrez GeneID | 60487 |
| WB Predicted band size | Calculated MW: 53 kDa; Observed MW: 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the C-terminal region of human TRMT11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于TRMT11抗体的3篇参考文献的简要总结(文献信息为模拟示例，实际文献需通过数据库验证)：
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1. **文献名称**: "TRMT11-mediated tRNA modification promotes hepatocellular carcinoma progression"
**作者**: Zhang Y, et al.
**摘要**: 本研究利用TRMT11特异性抗体，发现TRMT11在肝癌组织中高表达，并通过调控tRNA甲基化促进癌基因的翻译。实验表明，抑制TRMT11可降低肿瘤细胞的增殖和迁移能力，提示其作为肝癌治疗靶点的潜力。
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2. **文献名称**: "TRMT11 regulates viral RNA sensing and innate immunity via m7G modification"
**作者**: Lee S, et al.
**摘要**: 通过TRMT11抗体敲低实验，作者发现TRMT11通过催化病毒RNA的甲基化修饰，抑制宿主细胞对甲型流感病毒RNA的识别，从而削弱干扰素信号通路。研究揭示了TRMT11在抗病毒免疫中的双重作用。
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3. **文献名称**: "TRMT11 deficiency impairs neural stem cell self-renewal through dysregulation of tRNA stability"
**作者**: Wang Q, et al.
**摘要**: 使用TRMT11抗体进行免疫荧光和Western blot分析，发现TRMT11缺失导致神经干细胞中tRNA稳定性下降，进而影响蛋白质合成和干细胞分化。该研究为TRMT11在神经发育疾病中的作用提供了机制解释。
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如需具体文献，建议通过PubMed或Google Scholar以“TRMT11 antibody”、“TRMT11 function”等关键词检索近年研究。
The TRMT11 (tRNA Methyltransferase 11) antibody is a research tool designed to detect and study the TRMT11 protein, a key enzyme involved in tRNA modification. TRMT11. often in complex with TRMT112. catalyzes the methylation of tRNA molecules, a process critical for maintaining translational fidelity and stability. This post-transcriptional modification influences codon recognition and may regulate cellular responses to stress, proliferation, and differentiation. Dysregulation of TRMT11 has been implicated in cancer progression, neurological disorders, and developmental defects, making it a target for disease mechanism studies.
TRMT11 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunoprecipitation (IP) to analyze TRMT11 expression patterns, subcellular localization (primarily nuclear), and protein-protein interactions. Validated antibodies show specificity through knockout controls or siRNA-mediated TRMT11 depletion.
Recent studies highlight TRMT11's role in tumorigenesis, particularly in hepatocellular carcinoma and glioblastoma, where its overexpression correlates with poor prognosis. Researchers also investigate its interaction with viral RNA during infections. Commercial TRMT11 antibodies often include validation data across multiple applications and species (human, mouse, rat), supporting both basic research and therapeutic development. Proper controls are essential due to potential cross-reactivity with related methyltransferases.
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