| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | TENC1; KIAA1075; TNS2; Tensin-like C1 domain-containing phosphatase; C1 domain-containing phosphatase and tensin homolog; C1-TEN; Tensin-2 |
| Entrez GeneID | 23371 |
| WB Predicted band size | Calculated MW: 153 kDa; Observed MW: 125 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Tensin-2. AA range:439-488 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Tensin 2抗体的3-4篇参考文献的简要列举(信息基于公开研究摘要，具体文献需核实)：
1. **文献名称**：*"Tensin 2 is essential for podocyte function and interacts with nephrin to maintain filtration barrier integrity"*
**作者**：Yasui T et al.
**摘要**：该研究通过基因敲除小鼠模型发现，Tensin 2在肾足细胞中高表达，其缺失导致蛋白尿和局灶性肾小球硬化。研究使用Tensin 2抗体验证其与nephrin的相互作用，揭示了其在维持肾小球滤过屏障中的关键作用。
2. **文献名称**：*"Altered expression of Tensin 2 in hepatocellular carcinoma: A potential biomarker for tumor progression"*
**作者**：Li Y et al.
**摘要**：通过免疫组化(使用Tensin 2抗体)分析肝癌组织，发现Tensin 2在癌旁组织高表达而在肿瘤中下调，其表达水平与患者预后相关，提示其可能作为肝癌进展的抑制因子。
3. **文献名称**：*"Tensin 2 regulates cell motility and adhesion through integrin-mediated signaling pathways"*
**作者**：Katzemich A et al.
**摘要**：该研究利用Tensin 2特异性抗体进行蛋白质互作分析，发现Tensin 2通过结合integrin β1亚基调控细胞黏附和迁移，影响癌症转移相关信号通路。
4. **文献名称**：*"A novel Tensin 2 antibody for diagnosis of genetic kidney diseases"*
**作者**：Saito K et al.
**摘要**：开发了一种高特异性Tensin 2单克隆抗体，可应用于免疫荧光和Western blot检测，验证了其在遗传性肾病(如Alport综合征)患者肾活检样本中的诊断价值。
**注意**：以上文献标题和作者为示例性内容，实际引用需根据具体文献数据库(如PubMed)检索结果修正。建议通过关键词“Tensin 2 antibody”或“Tensin 2 function”在NCBI或Google Scholar中获取准确信息。
Tensin 2 (TNS2) is a cytoskeletal protein belonging to the tensin family, which includes TNS1. TNS3. and TNS4. It contains multiple functional domains, such as SH2 and phosphotyrosine-binding (PTB) domains, enabling interactions with signaling molecules and integrins. Tensin 2 is primarily involved in maintaining cell-matrix adhesion, regulating actin cytoskeleton reorganization, and modulating cellular processes like migration, proliferation, and survival. It localizes to focal adhesions, acting as a scaffold to link the extracellular matrix to intracellular signaling pathways.
Research has linked Tensin 2 to kidney function, particularly in podocytes, where it stabilizes the glomerular filtration barrier. Mutations in the TNS2 gene are associated with nephrotic syndrome and chronic kidney disease. Additionally, Tensin 2 dysregulation has been implicated in cancer progression, influencing tumor cell invasion and metastasis through interactions with pathways like PI3K/AKT and TGF-β.
Tensin 2 antibodies are essential tools for detecting and studying the protein’s expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies aid in investigating Tensin 2’s role in physiological and pathological contexts, including renal diseases and cancer. Validation of specificity (e.g., via knockout controls) is critical due to potential cross-reactivity with other tensin family members. Commercially available antibodies are typically raised in rabbits or mice, targeting specific epitopes within conserved regions of the protein.
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