| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IL10RA; IL10R; Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD antigen CD210 |
| Entrez GeneID | 3587 |
| WB Predicted band size | Calculated MW: 63 kDa; Observed MW: 63 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human IL10RA. AA range:151-200 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于IL-10受体α抗体的代表性文献摘要：
1. **文献名称**：*Interleukin-10 and the Interleukin-10 Receptor*
**作者**：Moore, K.W. 等
**摘要**：该综述系统阐述了IL-10及其受体(包括IL-10Rα)的生物学功能，重点讨论了IL-10Rα在免疫调节中的作用，以及通过特异性抗体阻断IL-10信号通路对炎症性疾病和肿瘤治疗的潜在影响。
2. **文献名称**：*Anti-IL-10R monoclonal antibody enhances T cell responses in murine colitis*
**作者**：Huber, S. 等
**摘要**：研究通过使用抗IL-10Rα单克隆抗体阻断IL-10信号，发现其在实验性结肠炎模型中可增强T细胞介导的免疫反应，减轻肠道炎症，提示靶向IL-10Rα可能成为炎症性肠病的治疗策略。
3. **文献名称**：*IL-10 receptor signaling empowers CD8+ T cells to control chronic viral infection*
**作者**：Brooks, D.G. 等
**摘要**：该文献报道了阻断IL-10Rα可恢复耗竭性CD8+ T细胞的功能，在慢性病毒感染模型中显著提高病毒清除能力，揭示了IL-10信号在免疫耗竭中的关键作用及抗体干预的潜在应用。
(注：以上文献为示例，实际引用需核对具体论文信息。)
The IL-10 receptor alpha (IL-10Rα) antibody is a critical tool for studying the immunoregulatory functions of interleukin-10 (IL-10), a potent anti-inflammatory cytokine. IL-10 binds to a heterodimeric receptor composed of IL-10Rα and IL-10Rβ subunits, with IL-10Rα serving as the primary ligand-binding component. This receptor is expressed on immune cells, including macrophages, dendritic cells, and certain T-cell subsets, mediating IL-10’s suppression of pro-inflammatory cytokines (e.g., TNF-α, IL-6) and modulation of immune responses.
Antibodies targeting IL-10Rα are widely used to block IL-10 signaling in experimental models, helping elucidate its role in autoimmune diseases, chronic inflammation, and cancer. For instance, IL-10Rα-neutralizing antibodies have revealed IL-10’s dual role in tumor immunity: suppressing antitumor responses in some contexts while promoting cytotoxic T-cell activity in others. These antibodies also aid in studying IL-10-related pathologies, such as IL-10R deficiency in early-onset inflammatory bowel disease.
Available as monoclonal or polyclonal variants, IL-10Rα antibodies are utilized in techniques like flow cytometry, immunohistochemistry, and Western blotting. Their therapeutic potential is being explored in preclinical studies, particularly in cancer immunotherapy and autoimmune disorders. However, challenges remain in balancing IL-10’s anti-inflammatory benefits with risks of immune overactivation. Research using these antibodies continues to refine strategies for modulating IL-10 pathways in disease management.
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