| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | FGF8; AIGF; Fibroblast growth factor 8; FGF-8; Androgen-induced growth factor; AIGF; Heparin-binding growth factor 8; HBGF-8 |
| Entrez GeneID | 2253 |
| WB Predicted band size | Calculated MW: 27 kDa; Observed MW: 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human FGF8. AA range:141-190 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇与FGF8抗体相关的研究文献概览(注：文献信息为模拟示例，实际引用需核实原文)：
1. **文献名称**：*"FGF8 expression and its antibody-mediated neutralization in mouse embryonic development"*
**作者**：Heikinheimo, M., et al.
**摘要**：研究通过FGF8特异性抗体定位了其在早期小鼠胚胎中的表达模式，发现FGF8在前脑和肢体芽发育中起关键作用，抗体中和实验导致胚胎神经管闭合缺陷。
2. **文献名称**：*"Immunohistochemical detection of FGF8 in human breast cancer tissues using a novel monoclonal antibody"*
**作者**：Yamaguchi, T.P., et al.
**摘要**：开发了一种高特异性抗人FGF8单克隆抗体，用于乳腺癌组织免疫组化分析，证实FGF8过表达与肿瘤血管生成和转移相关。
3. **文献名称**：*"Antibody blockade of FGF8 signaling disrupts limb morphogenesis in chick embryos"*
**作者**：Storm, E.E., et al.
**摘要**：利用FGF8抗体抑制鸡胚胎中FGF8信号通路，发现其导致肢体发育异常，揭示了FGF8在肢体极性建立中的必要性。
如需具体文献，建议通过PubMed或Google Scholar检索关键词“FGF8 antibody”+研究领域(如“cancer”“development”)获取最新或经典论文。
**Background of FGF8 Antibody**
The fibroblast growth factor 8 (FGF8) antibody is a tool used to detect and study FGF8. a member of the FGF family involved in embryonic development, cell proliferation, and tissue repair. FGF8 plays critical roles in regulating limb formation, neural patterning, and organogenesis during embryogenesis. Dysregulation of FGF8 signaling is linked to developmental disorders and cancers, including breast and prostate cancer.
FGF8 antibodies are designed to target specific epitopes of the FGF8 protein, enabling its detection in various experimental applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help researchers analyze FGF8 expression levels, localization, and interactions in tissues or cell lines. Polyclonal and monoclonal variants exist, with monoclonal antibodies offering higher specificity.
In research, FGF8 antibodies contribute to understanding developmental biology, particularly in model organisms like mice and zebrafish, where FGF8 knockout or overexpression studies reveal its role in morphogenesis. Additionally, they aid in investigating FGF8's involvement in oncogenesis, metastasis, and therapeutic resistance. Cross-reactivity with FGF8 orthologs across species (e.g., human, mouse) is a key consideration for experimental design.
Overall, FGF8 antibodies are vital for dissecting the protein's functional mechanisms and its implications in health and disease.
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