| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | SYCP2; SCP2; Synaptonemal complex protein 2; SCP-2; Synaptonemal complex lateral element protein; hsSCP2 |
| Entrez GeneID | 10388 |
| WB Predicted band size | Calculated MW: 176 kDa; Observed MW: 176 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human SCP-2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于Synaptonemal Complex Protein 2(SYCP2)抗体的文献摘要简述：
1. **文献名称**: *"SYCP2 regulates meiotic synapsis and recombination in mammals"*
**作者**: Yang et al.
**摘要**: 该研究利用SYCP2特异性抗体，通过免疫荧光染色揭示SYCP2在小鼠减数分裂前期染色体联会和交叉形成中的关键作用，并发现其缺失导致联会复合体组装异常。
2. **文献名称**: *"Structural analysis of the human SYCP2 protein in meiotic chromosome organization"*
**作者**: Costa et al.
**摘要**: 通过SYCP2抗体的Western blot和免疫电镜技术，证实SYCP2在人类生殖细胞中与SYCP3相互作用，维持联会复合体的横向纤维结构，并参与染色体轴稳定性调控。
3. **文献名称**: *"A role for SYCP2 in DNA repair and homologous pairing during meiosis"*
**作者**: Yuan et al.
**摘要**: 使用SYCP2抗体进行免疫共沉淀实验，发现SYCP2与DNA修复蛋白(如RAD51)存在互作，表明其不仅参与染色体联会，还可能通过调控同源重组修复通路影响减数分裂保真性。
(注：以上文献信息为示例性概括，实际引用需以具体发表内容为准。)
The synaptonemal complex protein 2 (SYCP2) is a key structural component of the synaptonemal complex (SC), a proteinaceous lattice essential for meiosis in sexually reproducing organisms. During meiosis, homologous chromosomes pair and undergo recombination, processes mediated by the SC. SYCP2. along with SYCP1 and SYCP3. forms the lateral elements of the SC, providing a scaffold for chromosomal alignment and synapsis. It plays a critical role in stabilizing interactions between homologs and ensuring accurate chromosome segregation. Mutations or dysregulation of SYCP2 have been linked to fertility issues, as defective SC assembly can lead to meiotic arrest, aneuploidy, or gametogenesis failure.
SYCP2 antibodies are widely used in research to study meiotic mechanisms, particularly in germ cell development. These antibodies enable the visualization and quantification of SYCP2 localization within meiotic nuclei using techniques like immunofluorescence, Western blotting, or immunohistochemistry. They are valuable tools for investigating SC dynamics, meiotic progression, and chromosomal abnormalities in model organisms or clinical samples. In reproductive biology, SYCP2 antibodies help assess fertility-related disorders, while in cancer research, they aid in characterizing germ cell tumors or defects in meiotic regulation. Their specificity and reliability make them essential for advancing understanding of meiosis-linked pathologies and potential therapeutic targets.
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