| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | SCML2; Sex comb on midleg-like protein 2 |
| Entrez GeneID | 10389 |
| WB Predicted band size | Calculated MW: 77 kDa; Observed MW: 77 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human SCML2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于SCML2抗体的3篇参考文献示例(注：部分信息为模拟示例，实际文献需通过学术数据库验证)：
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1. **文献名称**：*SCML2 regulates epigenetic silencing in germ cells through histone modification*
**作者**：Smith A, et al.
**摘要**：本研究利用SCML2特异性抗体，通过免疫沉淀和ChIP-seq技术，揭示了SCML2在生殖细胞中通过调控H3K27me3修饰参与表观遗传沉默的机制，为生殖发育异常提供分子机制解释。
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2. **文献名称**：*SCML2 as a tumor suppressor in prostate cancer: Antibody-based detection and functional analysis*
**作者**：Chen L, et al.
**摘要**：通过开发高特异性SCML2单克隆抗体，作者证明SCML2在前列腺癌组织中表达下调，并利用免疫组化及敲除实验验证其通过抑制癌基因通路发挥抑癌作用。
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3. **文献名称**：*Characterization of SCML2 isoforms using isoform-specific antibodies*
**作者**：Wang Y, et al.
**摘要**：该研究设计针对SCML2不同剪接变体的抗体，发现不同亚型在细胞核/质中的分布差异及其在DNA损伤修复中的特异性功能，为SCML2功能多样性提供实验依据。
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如需实际文献，建议通过PubMed或Google Scholar检索关键词“SCML2 antibody”或结合具体研究领域筛选。
The SCML2 (Sex Comb on Midleg-like 2) antibody is a tool used to study the SCML2 protein, a member of the Polycomb group (PcG) proteins involved in epigenetic regulation. SCML2 functions as a chromatin-associated protein that plays dual roles in gene silencing and activation. It interacts with Polycomb Repressive Complex 1 (PRC1) to mediate transcriptional repression through histone H2A ubiquitination, contributing to the maintenance of cellular identity and stem cell pluripotency. Simultaneously, SCML2 can act as a co-activator by binding to transcription factors, influencing differentiation and development.
SCML2 is particularly critical in germline development and spermatogenesis, where it regulates meiotic progression and chromatin dynamics. Aberrant SCML2 expression is linked to cancers, including prostate and ovarian cancers, underscoring its role in cell cycle control and tumor suppression.
Antibodies targeting SCML2 are essential for detecting its expression, localization, and interaction partners in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). These studies help unravel SCML2's context-dependent functions in epigenetic regulation, developmental biology, and disease mechanisms. Its dual regulatory nature makes SCML2 a key focus in understanding complex gene networks and potential therapeutic targets.
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