| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Platelet glycoprotein Ib beta chain (GP-Ib beta; GPIb-beta; GPIbB; Antigen CD42b-beta; CD antigen CD42c) |
| Entrez GeneID | 2812 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide from human protein at AA range: 90-150 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于CD42c(GPIX)抗体的虚构参考文献示例，内容基于学术文献常见主题合理模拟：
1. **"Structural and functional analysis of the platelet GPIb-IX-V complex"**
*作者：López JA, et al.*
*摘要*：本研究通过X射线晶体学解析了GPIb-IX-V复合物的三维结构，重点阐明了CD42c(GPIX)在稳定复合物构象中的作用。实验表明，CD42c抗体可特异性识别该亚基的胞外域，并抑制血小板与血管性血友病因子(vWF)的结合，提示其在抗血栓治疗中的潜在应用。
2. **"CD42c as a diagnostic marker in Bernard-Soulier syndrome"**
*作者：Nurden AT, et al.*
*摘要*：文章评估了CD42c抗体在诊断遗传性血小板疾病Bernard-Soulier综合征(BSS)中的应用。通过流式细胞术分析患者血小板，发现CD42c表达显著降低或缺失，证实其作为BSS分型的关键标志物，并为临床诊断提供了标准化流程。
3. **"Targeting CD42c in experimental thrombosis: Insights from monoclonal antibody studies"**
*作者：Ruggeri ZM, et al.*
*摘要*：研究开发了一种抗CD42c的单克隆抗体，并在小鼠模型中验证其抗血栓效果。结果显示，该抗体通过阻断GPIb-IX复合物的功能，显著减少动脉血栓形成，且未引起严重出血，为新型抗血小板药物研发提供了理论基础。
4. **"Genetic mutations in GPIX and their interaction with CD42c antibodies"**
*作者：Dong JF, et al.*
*摘要*：本文鉴定了GPIX基因的罕见突变位点，并利用CD42c抗体分析突变对血小板膜蛋白表达的影响。结果表明，某些突变导致抗体结合能力下降，进而影响血小板粘附功能，揭示了突变与临床出血表型的关联。
注：以上内容为模拟示例，实际文献需通过PubMed、Web of Science等平台检索关键词(如CD42c、GPIX、GPIb-IX、血小板抗体)获取。
The CD42c antibody targets the CD42c antigen, a subunit of the platelet glycoprotein (GP) Ib-IX-V complex, which is critical for platelet adhesion and thrombus formation. CD42c, also known as GPIbβ, is encoded by the GP1BB gene and non-covalently associates with GPIbα (CD42b) and GPIX (CD42a) to form the GPIb-IX complex on the platelet surface. This complex binds von Willebrand factor (VWF) under shear stress, initiating platelet adhesion at sites of vascular injury. CD42c plays a structural role in stabilizing the GPIb-IX complex and ensuring proper receptor expression.
Antibodies against CD42c are primarily used in research and diagnostics to study platelet function, monitor receptor expression, or investigate disorders like Bernard-Soulier syndrome (BSS), a rare bleeding disorder caused by mutations in GP1BB or related genes. In BSS, dysfunctional or reduced GPIb-IX-V complex leads to macrothrombocytopenia and impaired clotting. CD42c antibodies help identify molecular defects in such conditions. Additionally, these antibodies may have therapeutic potential in targeting platelet activation pathways to treat thrombosis. Their specificity makes them valuable tools for elucidating platelet biology and developing antiplatelet therapies.
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