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Rabbit Polyclonal DLEU7 Antibody

  • 中文名： DLEU7抗体
  • 别    名： Leukemia-associated protein 7 (Deleted in lymphocytic leukemia 7)
货号: IPDX23340
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesLeukemia-associated protein 7 (Deleted in lymphocytic leukemia 7)
Entrez GeneID220107
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human DLEU7. AA range:51-100
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是3篇涉及DLEU7抗体的文献示例(注：文献为模拟示例，实际需通过学术数据库检索确认)：

1. **"DLEU7 as a tumor suppressor in chronic lymphocytic leukemia"**

*作者：Smith A et al.*

摘要：研究证实DLEU7基因在13q14缺失的CLL患者中表达下调，其抗体检测显示蛋白水平降低，提示DLEU7可能通过调控细胞周期抑制肿瘤发生。

2. **"Immune-related gene DLEU7 modulates B-cell receptor signaling"**

*作者：Zhang L et al.*

摘要：通过抗体验证发现，DLEU7蛋白在B细胞活化中与信号分子相互作用，抗体阻断实验表明其可能通过NF-κB通路影响免疫应答。

3. **"Antibody-based detection of DLEU7 in autoimmune disorders"**

*作者：Garcia R et al.*

摘要：开发高特异性DLEU7单克隆抗体，用于流式细胞术和免疫组化，发现DLEU7在系统性红斑狼疮患者B细胞中异常表达，与疾病活动度相关。

**提示**：实际文献需在PubMed、Google Scholar等平台以"DLEU7 antibody"或"DLEU7 protein function"为关键词检索，重点关注抗体开发、分子机制或疾病关联研究。

背景信息

The DLEU7 (Deleted in Lymphocytic Leukemia 7) antibody is a tool used to study the DLEU7 protein, encoded by the *DLEU7* gene located in the chromosomal region 13q14. This region is frequently deleted in chronic lymphocytic leukemia (CLL) and other B-cell malignancies, suggesting a potential tumor-suppressive role. While the *DLEU7* gene itself is less characterized compared to neighboring genes like *DLEU2* (hosting the miR-15a/16-1 cluster), emerging evidence links its loss to dysregulated apoptosis and cell cycle progression in cancer cells. DLEU7 antibodies are typically monoclonal or polyclonal reagents designed to detect endogenous DLEU7 protein expression in research applications such as Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). These antibodies aid in elucidating DLEU7's biological functions, including its possible involvement in immune regulation and tumor suppression. Studies using DLEU7 antibodies have explored its reduced expression in CLL patients with 13q14 deletions, supporting its role as a biomarker for disease progression. However, functional insights remain limited, and research continues to clarify its molecular interactions and therapeutic relevance. Validation of antibody specificity via knockout controls is critical due to potential cross-reactivity with homologous proteins.

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