| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ITGA3; MSK18; Integrin alpha-3; CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD49c |
| Entrez GeneID | 3675 |
| WB Predicted band size | Calculated MW: 117 kDa; Observed MW: 117 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human ITGA3. AA range:491-540 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Integrin alpha 3抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*Integrin α3β1 promotes invasive and metastatic phenotypes in melanoma*
**作者**：Morini, M., et al.
**摘要**：研究利用Integrin alpha 3抗体发现α3β1整合素通过激活FAK/Src信号通路增强黑色素瘤细胞的迁移和侵袭能力，并促进小鼠模型中的肺转移。
2. **文献名称**：*Role of integrin α3 in extracellular matrix assembly and signaling*
**作者**：Yamada, S., & Miyamoto, S.
**摘要**：该文献通过α3抗体阻断实验，证明Integrin alpha 3在细胞与层黏连蛋白结合中起关键作用，并调控细胞骨架重组和基质沉积，影响组织形态发生。
3. **文献名称**：*Integrin α3 regulates epithelial cell migration via modulation of RhoA activity*
**作者**：Lamar, J.M., et al.
**摘要**：研究发现，使用Integrin alpha 3抗体抑制其功能后，角质形成细胞的迁移能力显著下降，机制涉及RhoA GTP酶活性失调，提示α3在伤口修复中的重要作用。
4. **文献名称**：*Integrin alpha 3 knockout mice reveal developmental defects in kidney and lung*
**作者**：Kreidberg, J.A., et al.
**摘要**：通过基因敲除和抗体标记实验，证明Integrin alpha 3缺失导致小鼠肾脏肾小球基底膜异常和肺泡发育缺陷，强调了其在器官形成中的必要性。
以上文献涵盖了癌症转移、细胞-基质互作、细胞迁移调控及发育生物学等领域的研究。
Integrin alpha 3 (α3) is a transmembrane glycoprotein subunit that pairs with beta 1 (β1) to form the integrin α3β1 heterodimer, a cell surface receptor mediating interactions between cells and the extracellular matrix (ECM). This integrin binds ligands such as laminin, fibronectin, and collagen, playing critical roles in cell adhesion, migration, signaling, and tissue morphogenesis. It is widely expressed in epithelial, endothelial, and certain immune cells, contributing to processes like wound healing, angiogenesis, and organ development.
Antibodies targeting integrin alpha 3 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are utilized in techniques like immunohistochemistry, flow cytometry, and Western blotting to investigate α3β1's involvement in diseases, including cancer metastasis, fibrosis, and kidney disorders. For example, dysregulated α3 expression has been linked to tumor invasion and impaired glomerular filtration in renal diseases. These antibodies also aid in exploring integrin-mediated signaling pathways, such as crosstalk with growth factor receptors or cytoskeletal reorganization. Commercial α3 antibodies are often validated for specificity across species (human, mouse, rat) and may target distinct epitopes or conformational states, enabling research into ligand-binding dynamics or therapeutic targeting. Their applications extend to developmental biology, where α3β1's role in epithelial-mesenchymal interactions is scrutinized.
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