| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CCL4L1; CCL4L; LAG1; SCYA4L1; CCL4L2; CCL4L; SCYA4L2; C-C motif chemokine 4-like; Lymphocyte activation gene 1 protein; LAG-1; Macrophage inflammatory protein 1-beta; MIP-1-beta; Monocyte adherence-induced protein 5-alpha; Small-inducible cytokine A4-like |
| Entrez GeneID | 388372 |
| WB Predicted band size | Calculated MW: 10 kDa; Observed MW: 10 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human CCL4L1/CCL4L2. AA range:31-80 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于CCL4L抗体的3篇示例文献(注：文献为虚构示例，仅用于演示格式)：
1. **文献名称**: *"Characterization of a novel monoclonal antibody against human CCL4L and its application in detecting genetic variants"*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种针对CCL4L蛋白的新型单克隆抗体，通过ELISA和免疫印迹验证其特异性，发现该抗体能区分CCL4L1和CCL4L2两种基因变体，为CCL4L相关疾病的机制研究提供工具。
2. **文献名称**: *"CCL4L expression in HIV-infected individuals: Correlation with antibody-dependent cellular cytotoxicity"*
**作者**: Lee B, et al.
**摘要**: 通过流式细胞术和免疫组化分析HIV感染者外周血样本，发现CCL4L蛋白水平与抗病毒抗体介导的细胞毒性(ADCC)活性呈正相关，提示CCL4L可能增强免疫清除病毒的能力。
3. **文献名称**: *"Differential roles of CCL4L isoforms in autoimmune disease models revealed by neutralizing antibodies"*
**作者**: Zhang Y, et al.
**摘要**: 采用靶向CCL4L1和CCL4L2的中和抗体，在小鼠类风湿性关节炎模型中证明，CCL4L1通过CCR5受体促进炎症，而CCL4L2具有抗炎作用，提示亚型特异性抗体的治疗潜力。
4. **文献名称**: *"Optimization of CCL4L detection in serum samples using a high-sensitivity ELISA protocol"*
**作者**: Gupta R, et al.
**摘要**: 开发了一种改进的ELISA检测方法，通过优化抗体配对(捕获抗体：CCL4L-C1;检测抗体：生物素化CCL4L-D3)，将血清中CCL4L的检测灵敏度提高至0.5 pg/mL，适用于临床样本低浓度检测。
CCL4L (C-C motif chemokine ligand 4-like) antibodies are tools used to detect and study the CCL4L protein, a variant of the CCL4 chemokine. CCL4L belongs to the CC chemokine family, which plays critical roles in immune responses by recruiting leukocytes, including T cells, monocytes, and eosinophils, to sites of inflammation or infection. CCL4L shares structural and functional similarities with CCL4 but exhibits genetic variability due to copy number variations (CNVs) in the human genome. Two primary isoforms, CCL4L1 and CCL4L2. are encoded by distinct genes on chromosome 17. differing by a few amino acids. These isoforms display altered receptor-binding affinities, potentially influencing their biological activity.
CCL4L interacts with chemokine receptors such as CCR5. a co-receptor for HIV entry, making it relevant in HIV research. Studies suggest CCL4L variants may modulate HIV susceptibility or disease progression by competitively inhibiting viral entry. Additionally, CCL4L is implicated in inflammatory and autoimmune diseases, cancer, and allergic responses, where its expression levels correlate with pathological conditions. Antibodies against CCL4L enable researchers to quantify protein expression, map tissue distribution (via techniques like ELISA, Western blot, or immunohistochemistry), and explore its role in disease models. However, cross-reactivity with CCL4 remains a challenge, necessitating careful validation of antibody specificity. Understanding CCL4L's functions through targeted antibodies contributes to insights into immune regulation and therapeutic development.
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