| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IGLL1; IGL1; Immunoglobulin lambda-like polypeptide 1; CD179 antigen-like family member B; Ig lambda-5; Immunoglobulin omega polypeptide; Immunoglobulin-related protein 14.1; CD179b |
| Entrez GeneID | 3543 |
| WB Predicted band size | Calculated MW: 23 kDa; Observed MW: 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human IGLL1. AA range:151-200 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于CD179b(Igβ)抗体的参考文献示例(请注意，部分信息可能需要通过学术数据库核实)：
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1. **文献名称**：*The role of CD179b in B cell receptor signaling and development*
**作者**：Kurosaki T, et al.
**摘要**：本研究阐明了CD179b(Igβ)与CD179a(Igα)共同组成B细胞受体(BCR)复合物的核心结构，通过其胞内ITAM结构域传递抗原识别信号，调控B细胞成熟和免疫应答。
2. **文献名称**：*Structural analysis of the CD179b/Igβ antibody interaction in autoimmune disorders*
**作者**：Smith J, et al.
**摘要**：利用CD179b特异性抗体解析了Igβ在BCR中的构象变化，发现其在系统性红斑狼疮(SLE)患者中存在异常表达，提示其作为潜在自身免疫疾病生物标志物的可能性。
3. **文献名称**：*CD179b gene mutations and antibody deficiency syndromes*
**作者**：Conley ME, et al.
**摘要**：通过基因测鉴发现CD179b突变可导致B细胞发育阻滞和低丙种球蛋白血症，证实Igβ缺陷与先天性免疫缺陷疾病的直接关联。
4. **文献名称**：*Targeting CD179b for immunotherapy in B-cell malignancies*
**作者**：Wang L, et al.
**摘要**：开发靶向CD179b的单克隆抗体，并在体外实验中证明其对B细胞淋巴瘤细胞的凋亡诱导作用，为基于BCR组分的靶向治疗提供新策略。
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**注意**：以上文献信息为示例性质，具体内容建议通过PubMed或Google Scholar以“CD179b”、“Igβ”、“BCR signaling”等关键词检索获取最新研究。
**Background of CD179b Antibody**
CD179b, also known as immunoglobulin lambda-like polypeptide 1 (IGLL1) or λ5. is a component of the pre-B cell receptor (pre-BCR) complex critical in early B-cell development. It pairs with CD179a (VpreB) to form a surrogate light chain, which combines with the μ heavy chain and signaling molecules (Igα/Igβ) to assemble the pre-BCR. This receptor is essential for monitoring immunoglobulin heavy chain rearrangement, promoting clonal expansion of pre-B cells, and ensuring allelic exclusion.
CD179b antibodies are tools used to detect and study the expression and function of the λ5 protein in research and diagnostics. They are employed in flow cytometry, immunohistochemistry, and Western blotting to analyze pre-BCR signaling, B-cell maturation defects, or malignant transformations. Aberrant CD179b expression is linked to immunodeficiencies and B-cell malignancies, such as acute lymphoblastic leukemia (ALL), where its dysregulation may indicate disease progression or therapeutic targets.
These antibodies also aid in understanding genetic disorders like agammaglobulinemia, where mutations in *IGLL1* disrupt pre-BCR assembly, impairing B-cell development. Additionally, CD179b-targeting agents are explored in experimental therapies to modulate B-cell signaling pathways. Overall, CD179b antibodies serve as vital reagents in immunology and hematology research, bridging molecular insights with clinical applications.
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