| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | GP5; Platelet glycoprotein V; GPV; Glycoprotein 5; CD42d |
| Entrez GeneID | 2814 |
| WB Predicted band size | Calculated MW: 61 kDa; Observed MW: 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human GP5. AA range:331-380 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
+ +
以下是关于CD42d抗体的模拟参考文献示例(内容为虚构，供参考)：
1. **标题**: *CD42d Antibody Characterization in Platelet Function Studies*
**作者**: Smith J, et al.
**摘要**: 研究利用CD42d单克隆抗体分析血小板GPIb-IX-V复合体的结构，发现其与von Willebrand因子结合的关键作用，为血小板减少症的机制提供了新见解。
2. **标题**: *Role of Anti-CD42d Autoantibodies in Immune Thrombocytopenia*
**作者**: Chen L, et al.
**摘要**: 探讨CD42d自身抗体在免疫性血小板减少症(ITP)患者中的存在及其对血小板破坏的影响，提示其可能作为疾病生物标志物。
3. **标题**: *Genetic Mutations of CD42d and Antibody-Based Detection Methods*
**作者**: Gonzalez R, et al.
**摘要**: 通过开发高特异性CD42d抗体，检测Bernard-Soulier综合征患者的基因突变导致的CD42d表达缺失，验证了抗体的诊断价值。
4. **标题**: *Therapeutic Targeting of CD42d in Thrombotic Disorders*
**作者**: Wang Y, et al.
**摘要**: 评估靶向CD42d的人源化抗体在抑制病理性血小板活化中的潜力，为抗血栓治疗提供了实验依据。
---
*注：以上为模拟文献，实际文献请通过PubMed/Google Scholar检索关键词(如“CD42d antibody”、“GPIBB platelet”)获取。*
CD42d, also known as glycoprotein Ibβ (GPIbβ), is a subunit of the platelet surface glycoprotein Ib-IX-V (GPIb-IX-V) complex, a critical receptor mediating platelet adhesion and thrombus formation. This transmembrane protein, encoded by the *GPIBB* gene on chromosome 22. pairs with GPIbα (CD42b) to form a functional subunit within the larger complex, which also includes GPIX (CD42a) and GPV (CD42c). The GPIb-IX-V complex binds von Willebrand factor (VWF) at sites of vascular injury, initiating platelet adhesion under shear stress and triggering intracellular signaling for platelet activation.
CD42d antibodies specifically target the GPIbβ subunit, playing roles in both research and diagnostics. In research, these antibodies are used to study the structure and function of the GPIb-IX-V complex, explore mechanisms of platelet activation, or model bleeding disorders like Bernard-Soulier syndrome (BSS), a rare autosomal recessive condition linked to mutations in *GPIBB*. Clinically, CD42d antibodies aid in diagnosing platelet disorders via flow cytometry by identifying surface protein deficiencies. Monoclonal anti-CD42d antibodies (e.g., clone HIP1) are also utilized in experimental settings to block receptor-ligand interactions or isolate platelets for functional assays. Their applications extend to investigating thrombotic diseases, evaluating antiplatelet therapies, and understanding platelet biology in hemostasis and inflammation.
×
