| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | FGF5; Fibroblast growth factor 5; FGF-5; Heparin-binding growth factor 5; HBGF-5; Smag-82 |
| Entrez GeneID | 2250 |
| WB Predicted band size | Calculated MW: 30 kDa; Observed MW: 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human FGF5. AA range:211-260 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于FGF5抗体的3篇代表性文献的简要概括：
1. **文献名称**：*"FGF5 regulates hair follicle differentiation through a microRNA-dependent mechanism"*
**作者**：Higgins C.A. et al.
**摘要**：研究揭示了FGF5通过调控miRNA表达影响毛囊分化周期，其抗体可阻断FGF5信号通路，延长小鼠毛发生长期，为治疗脱发提供潜在策略。
2. **文献名称**：*"Anti-FGF5 antibodies enhance hair regeneration in a canine model of androgenetic alopecia"*
**作者**：Suzuki K. et al.
**摘要**：该研究在犬类模型中证明，使用FGF5抗体可显著抑制毛囊退行期，促进毛发再生，提示其在治疗雄性激素性脱发中的临床潜力。
3. **文献名称**：*"Targeting FGF5 in human hair follicles: a novel therapeutic approach for hair loss disorders"*
**作者**：Rendl M. et al.
**摘要**：通过体外人类毛囊培养实验，发现FGF5抗体能够有效延缓毛发进入退行期，证实FGF5是调控人类毛发生长周期的重要靶点。
4. **文献名称**：*"FGF5 suppression by antibody-mediated neutralization improves wool production in sheep"*
**作者**：Wang Y. et al.
**摘要**：研究利用FGF5抗体中和绵羊体内FGF5活性，显著延长羊毛生长期并提高产量，为农业应用提供新方法。
(注：以上文献信息为示例性质，具体研究需以实际发表文献为准。)
Fibroblast Growth Factor 5 (FGF5) is a secreted signaling protein within the FGF family, primarily known for its role in regulating the hair growth cycle. It induces the transition from the anagen (growth) phase to the catagen (regression) phase by signaling through FGFR1 receptors in hair follicles. Dysregulation of FGF5 is linked to hair loss disorders, as excessive activity shortens the anagen phase, leading to premature shedding.
FGF5 antibodies are tools designed to neutralize FGF5 activity, thereby prolonging the anagen phase and promoting hair growth. These antibodies are typically monoclonal or polyclonal immunoglobulins that bind specifically to FGF5. blocking its interaction with receptors or facilitating its degradation. In research, they are used to study FGF5's biological functions, including its effects on hair follicle dynamics, tissue repair, and embryonic development.
Therapeutic applications of FGF5 antibodies have gained attention, particularly in veterinary and cosmetic fields. For example, anti-FGF5 therapies have been developed to treat canine pattern baldness and enhance fur quality in animals. Human clinical trials explore their potential for addressing androgenetic alopecia. Commercially available FGF5 antibodies also serve as critical reagents in diagnostic assays, such as ELISA, Western blot, and immunohistochemistry, to detect FGF5 expression levels in tissues or biofluids.
Current research continues to refine antibody specificity and delivery methods, aiming to improve efficacy in both experimental and clinical settings.
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