| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CDH5; Cadherin-5; 7B4 antigen; Vascular endothelial cadherin; VE-cadherin; CD antigen CD144 |
| Entrez GeneID | 1003 |
| WB Predicted band size | Calculated MW: 88 kDa; Observed MW: 120 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDH5. AA range:697-746 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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1. **文献名称**: "VE-cadherin antibodies induce beta-catenin phosphorylation and endothelial barrier disruption"
**作者**: Gavard, J., et al.
**摘要**: 研究通过VE-cadherin(CDH5)抗体处理内皮细胞，发现其诱导β-catenin磷酸化并破坏细胞间连接，揭示了VE-cadherin在调控血管通透性中的关键作用。
2. **文献名称**: "CDH5 gene knockout in endothelial cells alters tumor angiogenesis and metastasis"
**作者**: Carmeliet, P., et al.
**摘要**: 利用Cdh5特异性抗体验证基因敲除模型，证明VE-cadherin缺失导致肿瘤血管异常生成并抑制转移，强调其在肿瘤微环境中的功能。
3. **文献名称**: "A monoclonal antibody to cadherin-5 inhibits leukocyte transmigration in vitro and in vivo"
**作者**: Liao, F., et al.
**摘要**: 开发一种抗CDH5单克隆抗体，体外和体内实验显示其阻断白细胞跨内皮迁移，为抗炎治疗提供潜在靶点。
4. **文献名称**: "VE-cadherin-directed antibody improves drug delivery and efficacy in murine breast cancer models"
**作者**: Meng, Y., et al.
**摘要**: 通过靶向VE-cadherin的抗体增强肿瘤血管通透性，促进化疗药物渗透，显著提高乳腺癌模型治疗效果。
注：以上文献为示例，实际引用需核对具体数据库(如PubMed)获取完整信息。
Cadherin 5. also known as VE-cadherin (vascular endothelial cadherin) or CDH5. is a calcium-dependent cell adhesion protein predominantly expressed in vascular endothelial cells. As a key component of adherens junctions, it plays a critical role in maintaining vascular integrity, regulating endothelial barrier function, and mediating cell-cell interactions during angiogenesis and vascular development. Structurally, it consists of five extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail that interacts with catenins (e.g., β-catenin, p120-catenin) to link the actin cytoskeleton, ensuring mechanical stability and signal transduction.
Cadherin 5 antibodies are essential tools for studying endothelial biology and vascular-related pathologies. These antibodies specifically target epitopes on the extracellular or intracellular domains of Cadherin 5. enabling applications such as immunohistochemistry (IHC), immunofluorescence (IF), Western blot (WB), and flow cytometry. They are widely used to investigate angiogenesis, tumor vasculature, and endothelial dysfunction in conditions like cancer, inflammation, and cardiovascular diseases. In research, Cadherin 5 antibodies help visualize vascular networks, assess endothelial permeability, and study signaling pathways involving VEGF or Wnt. Therapeutic potential is also explored, as modulating Cadherin 5 interactions may influence vascular remodeling or barrier regulation. Validation of antibody specificity remains crucial due to structural similarities among cadherin family members.
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