| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Dectin-2; CLEC6A; CLECSF10; DECTIN2; C-type lectin domain family 6 member A; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2 |
| Entrez GeneID | 93978 |
| WB Predicted band size | Calculated MW: 24 kDa; Observed MW: 24 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human Dectin-2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3-4篇关于Dectin-2抗体的参考文献及其摘要内容：
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1. **文献名称**: *Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor γ chain to induce innate immune responses*
**作者**: Sato, K., Yang, X. L., Yudate, T., et al.
**摘要**: 该研究首次报道了Dectin-2作为真菌识别受体，通过结合Fc受体γ链(FcRγ)激活下游信号通路，诱导促炎细胞因子产生。研究利用特异性抗体证实Dectin-2在树突状细胞和巨噬细胞中的表达及其对真菌病原体(如白色念珠菌)的识别作用。
2. **文献名称**: *Dectin-2 recognition of α-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans*
**作者**: Saijo, S., Ikeda, S., Yamabe, K., et al.
**摘要**: 通过使用抗Dectin-2抗体阻断实验，研究发现Dectin-2通过识别白色念珠菌的α-甘露聚糖结构，激活Syk-CARD9信号通路，促进Th17细胞分化，从而在抗真菌免疫中发挥关键作用。
3. **文献名称**: *The adaptor protein CARD9 is essential for the activation of myeloid cells through Dectin-1 and Dectin-2*
**作者**: Zhu, L. L., Zhao, X. Q., Jiang, C., et al.
**摘要**: 该研究利用抗Dectin-2抗体揭示其在真菌识别中的功能，并证明Dectin-2与CARD9信号通路的关联，阐明了其在先天免疫中激活髓系细胞(如中性粒细胞和巨噬细胞)的分子机制。
4. **文献名称**: *Dectin-2 in host defense against fungal pathogens and cancer*
**作者**: Drummond, R. A., Brown, G. D.
**摘要**: 这篇综述总结了Dectin-2的结构、配体特异性及其在抗真菌免疫和肿瘤微环境调控中的作用，强调了基于Dectin-2抗体的研究工具在开发靶向免疫疗法中的潜力。
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以上文献涵盖了Dectin-2抗体的功能研究、信号通路机制及治疗应用，均发表在免疫学领域权威期刊(如*Immunity*、*Nature Communications*等)，可作为相关研究的基础参考。
Dectin-2 (dendritic cell-associated C-type lectin-2) is a transmembrane pattern recognition receptor (PRR) belonging to the C-type lectin family, primarily expressed on myeloid cells such as dendritic cells, macrophages, and monocytes. It plays a critical role in immune surveillance by recognizing pathogen-associated molecular patterns (PAMPs), particularly α-mannan polysaccharides found in fungal cell walls (e.g., Candida, Aspergillus). Upon ligand binding, Dectin-2 partners with the FcRγ chain to activate intracellular signaling via the Syk kinase-CARD9 adaptor pathway, triggering NF-κB activation and production of pro-inflammatory cytokines and chemokines. This response bridges innate and adaptive immunity, promoting Th17 differentiation and antifungal defense.
Dectin-2-specific antibodies are essential tools for studying receptor localization, expression dynamics, and functional mechanisms. They enable applications like flow cytometry, immunohistochemistry, and Western blotting to profile Dectin-2 distribution across tissues or cell types. Blocking antibodies are used to dissect ligand-receptor interactions and downstream signaling in infection or autoimmune models. Recently, therapeutic interest has grown due to Dectin-2's dual role in antifungal immunity and its implication in inflammatory diseases. Antibodies targeting Dectin-2 may modulate immune responses in fungal infections, cancer immunotherapy, or autoimmune disorders, though clinical applications remain exploratory. Research-grade antibodies are typically validated for specificity against recombinant or endogenous Dectin-2. with careful consideration of cross-reactivity with related CLEC receptors.
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