| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | GDF6; GDF16; Growth/differentiation factor 6; GDF-6; Growth/differentiation factor 16 |
| Entrez GeneID | 392255 |
| WB Predicted band size | Calculated MW: 51 kDa; Observed MW: 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human GDF6. AA range:311-360 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于GDF6抗体的3篇参考文献示例(注：文献信息为模拟生成，仅供参考)：
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1. **文献名称**: *GDF6 Antibody Characterization in Zebrafish Craniofacial Development*
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性GDF6抗体分析斑马鱼胚胎中GDF6蛋白的表达模式，发现其与颅面软骨发育密切相关，抗体通过免疫组化验证了GDF6在颅神经嵴细胞迁移中的动态分布。
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2. **文献名称**: *Role of GDF6 in Osteoarthritis: Insights from Antibody-Mediated Inhibition*
**作者**: Chen L, et al.
**摘要**: 通过抗GDF6抗体抑制人软骨细胞中的GDF6活性，研究发现GDF6信号异常上调与关节退行性变相关，抗体阻断实验表明其可能成为骨关节炎治疗的潜在靶点。
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3. **文献名称**: *Development of a High-Specificity GDF6 Monoclonal Antibody for Cancer Biomarker Screening*
**作者**: Wang Y, et al.
**摘要**: 报道了一种新型GDF6单克隆抗体的开发与验证，该抗体在多种癌症组织(如黑色素瘤、胶质瘤)中显示出高灵敏度和特异性，可用于临床样本中GDF6过表达的检测与预后评估。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“GDF6 antibody”获取最新研究。
**Background of GDF6 Antibody**
Growth differentiation factor 6 (GDF6), a member of the TGF-β superfamily, plays critical roles in embryonic development, particularly in skeletal and joint formation, limb patterning, and axial specification. It is encoded by the *GDF6* gene and functions as a secreted signaling protein that regulates cell differentiation, proliferation, and tissue morphogenesis via binding to BMP (bone morphogenetic protein) receptors. Dysregulation of GDF6 is linked to congenital skeletal malformations, scoliosis, and osteoarthritis.
GDF6 antibodies are immunological tools designed to detect and study the expression, localization, and function of GDF6 proteins in biological samples. These antibodies are widely used in research applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA to investigate GDF6's role in developmental biology, disease mechanisms, and regenerative medicine. They are particularly valuable in studies exploring skeletal development, cartilage repair, and stem cell differentiation.
Commercially available GDF6 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of human, mouse, or rat GDF6. Validation often includes knockout controls, specificity assays, and cross-reactivity tests. Researchers rely on these antibodies to elucidate GDF6's interaction with downstream pathways (e.g., SMAD signaling) and its potential as a therapeutic target for bone or joint disorders.
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