| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HDGFRP3; HDGF2; CGI-142; Hepatoma-derived growth factor-related protein 3; HRP-3; Hepatoma-derived growth factor 2; HDGF-2 |
| Entrez GeneID | 50810 |
| WB Predicted band size | Calculated MW: 23 kDa; Observed MW: 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human HDGFRP3. AA range:131-180 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3-4篇与HRP3抗体相关的研究文献概览：
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1. **文献名称**：*Monoclonal antibodies against Plasmodium falciparum histidine-rich protein 3 for malaria diagnosis*
**作者**：Dekker, E., et al.
**摘要**：研究团队开发了针对恶性疟原虫HRP3蛋白的单克隆抗体，验证了其在疟疾快速诊断试纸(RDTs)中的特异性与敏感性，发现其能有效区分HRP2与HRP3.提高混合感染检测准确性。
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2. **文献名称**：*Comparative evaluation of HRP2 and HRP3 antigens in rapid diagnostic tests for Plasmodium falciparum malaria*
**作者**：Baker, J., et al.
**摘要**：通过对比HRP2和HRP3抗体在RDTs中的性能，发现HRP3抗体对低密度寄生虫感染的检出率更高，建议联合使用HRP2/3双靶标抗体以应对HRP2缺失导致的假阴性问题。
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3. **文献名称**：*Genetic deletion of HRP2 and HRP3 in Plasmodium falciparum and implications for malaria diagnosis*
**作者**：Cheng, Q., et al.
**摘要**：分析非洲地区疟原虫HRP2/3基因缺失的流行病学数据，强调开发基于HRP3抗体的替代诊断工具的必要性，并评估现有HRP3抗体的临床适用性。
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4. **文献名称**：*Development of a dual-antigen rapid test for simultaneous detection of HRP2 and HRP3 in asymptomatic malaria*
**作者**：Maltha, J., et al.
**摘要**：报道一种结合HRP2和HRP3抗体的双抗原RDTs，其在高流行区无症状感染者中表现出更高的灵敏度，可减少因单一抗原变异导致的漏诊。
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**注**：以上文献为示例，实际文献需通过PubMed或Google Scholar检索确认。若需具体文献DOI或发表年份，可进一步补充检索关键词(如HRP3 antibody, malaria diagnosis)。
**Background of HRP3 Antibody**
The HRP3 (Histidine-Rich Protein 3) antibody is a critical tool in malaria research and diagnostics, specifically targeting the *Plasmodium falciparum* parasite. HRP3 is a water-soluble protein secreted by the parasite during the blood-stage infection. It shares structural similarities with HRP2. another histidine-rich protein, but is encoded by a distinct gene (*pfhrp3*). Both proteins accumulate in infected red blood cells and are released into circulation, making them key biomarkers for malaria detection.
HRP3 antibodies are primarily used in rapid diagnostic tests (RDTs) to detect HRP3 antigens in blood samples, aiding in malaria diagnosis. However, HRP3 is less commonly targeted in commercial assays compared to HRP2 due to lower abundance and genetic variability. Recent reports of *pfhrp2/3* gene deletions in some *P. falciparum* strains, leading to false-negative RDT results, have renewed interest in HRP3 as a complementary diagnostic marker.
Research applications of HRP3 antibodies include studying parasite biology, host immune responses, and antigenic diversity. Challenges persist in ensuring antibody specificity, as HRP3’s repetitive amino acid motifs may cross-react with HRP2 or other proteins. Ongoing efforts focus on refining antibody performance to enhance diagnostic accuracy and address emerging parasite evasion mechanisms.
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