| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HSPBAP1; PASS1; HSPB1-associated protein 1; 27 kDa heat shock protein-associated protein 1; Protein associated with small stress protein 1 |
| Entrez GeneID | 79663 |
| WB Predicted band size | Calculated MW: 55 kDa; Observed MW: 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human HSPBAP1. AA range:321-370 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
+ +
以下是模拟生成的关于HspBAP1抗体的参考文献示例(仅供参考，实际文献需通过学术数据库验证)：
---
1. **文献名称**: *HspBAP1 expression in renal cell carcinoma: A potential biomarker for tumor progression*
**作者**: Kumar A, et al.
**摘要**: 研究通过HspBAP1抗体检测发现，HspBAP1在肾细胞癌中高表达，并与肿瘤侵袭性和患者预后不良相关，提示其可能作为癌症进展的生物标志物。
2. **文献名称**: *HspBAP1 regulates oxidative stress-induced apoptosis via interaction with HSP27*
**作者**: Chen L, et al.
**摘要**: 利用HspBAP1抗体进行免疫共沉淀实验，揭示HspBAP1通过结合HSP27调控氧化应激下的细胞凋亡通路，为相关疾病治疗提供分子机制依据。
3. **文献名称**: *Loss of HspBAP1 disrupts proteostasis and promotes neurodegeneration in Drosophila models*
**作者**: Smith J, et al.
**摘要**: 通过抗体标记发现HspBAP1缺失导致果蝇模型中蛋白质稳态失衡，加速神经退行性病变，表明其在神经保护中的关键作用。
---
**建议**：以上内容为示例，实际文献请通过PubMed、Google Scholar等平台以“HspBAP1 antibody”或“HspBAP1 function”为关键词检索，并优先选择近5年高被引研究。
The HspBAP1 (HSPB1-associated protein 1) antibody is a tool used to study the HspBAP1 protein, a poorly understood but evolutionarily conserved molecule implicated in cellular stress responses and cancer biology. HspBAP1 interacts with HSP27 (HSPB1), a member of the small heat shock protein family involved in protein folding, apoptosis, and cytoskeletal organization. This interaction modulates HSP27’s chaperone activity and influences stress-adaptive mechanisms.
HspBAP1 is ubiquitously expressed, with elevated levels observed in certain cancers, such as prostate and breast carcinomas, suggesting a potential role in tumor progression. Its function remains debated; some studies propose it acts as a tumor suppressor by promoting HSP27 ubiquitination and degradation, while others associate it with pro-survival signaling under oxidative stress.
Antibodies targeting HspBAP1 enable researchers to detect its expression, subcellular localization (primarily nuclear), and interaction partners via techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. These tools have been critical in exploring HspBAP1’s regulatory effects on HSP27-dependent pathways, including MAPK signaling and apoptosis. Commercial antibodies are typically raised against specific epitopes, often validated using knockout or knockdown controls to ensure specificity. Current research focuses on clarifying HspBAP1’s dual roles in stress response and cancer, aiming to uncover therapeutic targets for diseases linked to HSP27 dysregulation.
×
