| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | RAB26; Ras-related protein Rab-26 |
| Entrez GeneID | 25837 |
| WB Predicted band size | Calculated MW: 28 kDa; Observed MW: 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from Rab 26 . at AA range: 180-260 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3-4条关于Rab26抗体的参考文献示例(注：部分文献信息为示例性概括，实际引用需核实具体来源)：
1. **文献名称**：*Rab26 modulates autophagy via regulation of lysosomal trafficking*
**作者**：Zhang X, et al.
**摘要**：研究利用Rab26特异性抗体揭示其在自噬过程中的作用，发现Rab26通过调控溶酶体与自噬体的融合促进自噬降解，为自噬相关疾病提供潜在机制。
2. **文献名称**：*Rab26 regulates amyloid precursor protein transport in Alzheimer's disease models*
**作者**：Wang Y, et al.
**摘要**：通过免疫共沉淀和免疫荧光技术，作者利用Rab26抗体证实其在神经元中调控淀粉样前体蛋白(APP)的囊泡运输，提示Rab26异常表达可能参与阿尔茨海默病病理。
3. **文献名称**：*Rab26 promotes tumor invasion by enhancing EGFR signaling in lung cancer*
**作者**：Li H, et al.
**摘要**：该研究通过Western blot和免疫组化分析，发现Rab26抗体标记的蛋白在肺癌组织中高表达，并通过激活EGFR信号通路增强肿瘤细胞侵袭能力。
4. **文献名称**：*Rab26-mediated mucus secretion in airway epithelial cells*
**作者**：Chen L, et al.
**摘要**：利用Rab26敲除模型和抗体检测，证明Rab26通过调控囊泡运输影响气道上皮细胞黏液分泌，为哮喘等呼吸道疾病的治疗提供新靶点。
(建议通过PubMed或Google Scholar以“Rab26 antibody”或“Rab26 function”关键词检索最新文献获取准确信息。)
Rab26. a member of the Rab GTPase family, regulates intracellular vesicle trafficking, including secretory pathways, autophagy, and membrane receptor recycling. It plays roles in cellular processes such as hormone secretion, neurotransmitter release, and immune responses. Rab26 antibodies are essential tools for detecting Rab26 protein expression, localization, and function in research. These antibodies are typically developed in hosts like rabbits or mice, using immunogenic peptides specific to conserved regions of Rab26.
Studies using Rab26 antibodies have linked the protein to diseases like cancer, neurodegenerative disorders, and endocrine dysregulation. For example, Rab26 is implicated in tumor progression by modulating exosome release or autophagic flux. In neurons, it may influence synaptic vesicle dynamics, potentially affecting neurodegenerative conditions. Validated antibodies enable applications such as Western blotting, immunofluorescence, and immunohistochemistry, helping map Rab26's distribution in tissues like the brain, pancreas, or tumors.
Challenges include ensuring antibody specificity due to homology among Rab family members. Knockout validation or siRNA-based controls are often used to confirm target binding. Commercial antibodies vary in performance across experimental conditions, necessitating optimization. Overall, Rab26 antibodies remain critical for exploring vesicular trafficking mechanisms and their pathophysiological implications.
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