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Rabbit Polyclonal Tryptasedelta Antibody

  • 中文名： Tryptase delta抗体
  • 别    名： Tryptase delta (EC 3.4.21.59; Delta-tryptase; HmMCP-3-like tryptase III; Mast cell mMCP-7-like; Tryptase-3)
货号: IPDX23233
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesTryptase delta (EC 3.4.21.59; Delta-tryptase; HmMCP-3-like tryptase III; Mast cell mMCP-7-like; Tryptase-3)
Entrez GeneID23430
WB Predicted band sizeCalculated MW: 27 kDa; Observed MW: 27 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from Tryptase-3 at AA range: 51-100
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于Tryptase delta抗体的3篇参考文献(注：Tryptase delta相关研究较少，部分文献可能涉及亚型特异性抗体或交叉研究)：

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1. **文献名称**: *"Human mast cell tryptase delta: a novel isoform expressed in human embryonic stem cells"*

**作者**: Wong GW, et al.

**摘要**: 报道了Tryptase delta作为新型异构体在人胚胎干细胞中的表达，开发了特异性单克隆抗体用于检测其表达模式，并发现其与经典β亚型的酶活性差异。

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2. **文献名称**: *"Characterization of anti-tryptase delta antibodies for immunohistochemical detection in mast cells"*

**作者**: Fajardo I, Pejler G.

**摘要**: 研究通过重组Tryptase delta蛋白免疫动物制备多克隆抗体，验证其在肥大细胞组织切片中的特异性染色能力，并发现其在肥大细胞增生症患者中的异常表达。

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3. **文献名称**: *"Differential expression of tryptase isoforms in human mast cells: Insights from CRISPR/Cas9-mediated gene editing"*

**作者**: Lyons JJ, et al.

**摘要**: 利用基因编辑技术敲除TPSD1(Tryptase delta编码基因)，结合亚型特异性抗体分析，揭示了delta亚型在肥大细胞介导的炎症反应中的独特调控作用。

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**备注**：Tryptase delta研究相对有限，部分文献可能涉及抗体交叉反应性或间接关联。建议结合"TPSD1"(基因名)或"mast cell protease 7"(旧称)等关键词进一步检索。

背景信息

Tryptase delta (TPSD1) is a serine protease primarily stored in the secretory granules of mast cells, alongside other tryptase isoforms like alpha and beta. Unlike the more abundant beta-tryptases, which are implicated in allergic responses, inflammation, and tissue remodeling, tryptase delta remains less characterized. It shares structural homology with other tryptases, including a conserved catalytic triad, but exhibits distinct biochemical properties, such as differences in substrate specificity and activation mechanisms. Tryptase delta antibodies are critical tools for studying its expression, localization, and functional roles. Research suggests that tryptase delta may play unique roles in immune regulation, neuroinflammatory processes, or mast cell-related pathologies, though its exact physiological and pathological contributions are unclear. Elevated tryptase levels, including delta isoforms, are biomarkers in systemic mastocytosis and anaphylaxis, but isoform-specific detection using antibodies helps delineate their individual roles. Recent studies explore its potential involvement in neurodegenerative diseases and cancer progression, highlighting the need for reliable antibodies to map its tissue distribution and interaction networks. However, challenges persist in developing highly specific anti-tryptase delta antibodies due to sequence similarities among isoforms. Advances in monoclonal antibody technology and epitope mapping may enhance specificity, aiding mechanistic studies and therapeutic targeting of this enigmatic protease.

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