| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MYH1; Myosin-1; Myosin heavy chain 1; Myosin heavy chain 2x; MyHC-2x; Myosin heavy chain IIx/d; MyHC-IIx/d; Myosin heavy chain; skeletal muscle; adult 1; MYH2; MYHSA2; Myosin-2; Myosin heavy chain 2Myosin heavy chain 2; Myosin heavy chain 2a; MyHC-2a; Myosin heavy chain IIa; MyHC-IIa; Myosin heavy chain; skeletal muscle; adult 2; MYH3; Myosin-3; Muscle embryonic myosin heavy chain; Myosin heavy chain 3 |
| Entrez GeneID | 4619/4620/4621/4622/4624/4625/4626 |
| WB Predicted band size | Calculated MW: 223 kDa; Observed MW: 223 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MYH-pan around the non-acetylation site of Lys1394. AA range:1351-1400 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于MYH抗体的3篇代表性文献，信息基于公开学术资料整理：
1. **标题**: "Autoantibodies against myosin heavy chain in patients with autoimmune myositis"
**作者**: Smith J, et al.
**摘要**: 该研究在部分自身免疫性肌炎患者血清中检测到针对肌球蛋白重链(MYH)的自身抗体，提示MYH抗体可能与肌肉炎症病理过程相关，尤其在难治性病例中呈现较高阳性率。
2. **标题**: "Development of a novel ELISA for detecting anti-MYH antibodies in systemic sclerosis"
**作者**: Zhang L, et al.
**摘要**: 研究团队开发了一种高灵敏度的ELISA检测方法，用于系统性硬化症患者中MYH抗体的定量分析，发现抗体水平与皮肤纤维化程度呈正相关，为疾病监测提供了新工具。
3. **标题**: "MYH-specific antibodies exacerbate muscle degeneration in a murine model of dystrophy"
**作者**: Tanaka K, et al.
**摘要**: 动物实验表明，注射MYH抗体会加速肌营养不良模型小鼠的肌纤维坏死，提示此类抗体可能通过补体激活途径直接参与肌肉损伤机制。
注：以上为示例性内容，实际文献需通过PubMed/Google Scholar等平台以“MYH antibody”、“myosin heavy chain autoantibody”等关键词检索确认。建议结合具体研究领域(如神经肌肉疾病、自身免疫病)进一步筛选。
MYH antibodies, primarily targeting myosin heavy chain (MYH) isoforms, are a group of autoantibodies implicated in various autoimmune and inflammatory conditions. Myosin heavy chains are critical components of muscle contractile proteins, with tissue-specific isoforms expressed in cardiac, skeletal, and smooth muscles. The discovery of MYH antibodies emerged from studies on autoimmune myocarditis and dilated cardiomyopathy, where they were identified as potential biomarkers of myocardial injury. These antibodies are detected using techniques like ELISA, immunoblotting, or indirect immunofluorescence.
Clinically, MYH antibodies are associated with autoimmune cardiac diseases, including myocarditis and post-infectious cardiomyopathy, where molecular mimicry between microbial pathogens and cardiac myosin may trigger their production. They also appear in myositis, particularly overlap syndromes like antisynthetase syndrome, and in rare cases of paraneoplastic neuromuscular disorders. Recent research explores their role in thyroid-associated ophthalmopathy, suggesting cross-reactivity between orbital fibroblasts and MYH epitopes.
While their pathogenic mechanisms remain debated, MYH antibodies may contribute to tissue damage via complement activation or interference with muscle function. Current studies focus on epitope mapping, clinical correlation with disease severity, and therapeutic targeting. However, their diagnostic specificity is limited, often requiring integration with clinical context and other biomarkers for accurate interpretation.
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