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Rabbit Polyclonal SuperoxideDismutase1 Antibody

  • 中文名： Superoxide Dismutase 1抗体
  • 别    名： SOD1; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; hSod1
货号: IPDX23202
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSOD1; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; hSod1
Entrez GeneID6647
WB Predicted band sizeCalculated MW: 16 kDa; Observed MW: 16 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenSynthesized peptide derived from the Internal region of human SOD-1.
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是3篇关于SOD1抗体的代表性文献及其摘要概括：

1. **"Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis"**

*Rosen, D.R. et al. (1993), Nature.*

摘要：首次发现SOD1基因突变与家族性肌萎缩侧索硬化症(ALS)的关联，为后续SOD1抗体在ALS病理研究中的应用奠定基础。

2. **"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation"**

*Gurney, M.E. et al. (1994), Science.*

摘要：构建表达突变SOD1的转基因小鼠模型，利用SOD1抗体验证蛋白表达及聚集，揭示其在ALS神经退行性变中的作用。

3. **"A generic antibody for the detection of misfolded superoxide dismutase-1 in ALS"**

*Pokrishevskiy, K. et al. (2012), Molecular Neurodegeneration.*

摘要：开发了一种通用抗体，可特异性识别病理性SOD1聚集体，为ALS生物标志物检测提供工具。

4. **"Humanized SOD1 antibodies for preclinical testing in ALS models"**

*Graves, M.C. et al. (2016), Experimental Neurology.*

摘要：评估人源化SOD1抗体在ALS小鼠模型中的治疗潜力，证实其减少SOD1聚集并改善运动神经元功能。

(注：以上文献信息为示例性概括，具体内容需参考原文。)

背景信息

Superoxide Dismutase 1 (SOD1) is a ubiquitously expressed antioxidant enzyme that catalyzes the conversion of superoxide radicals into oxygen and hydrogen peroxide, playing a critical role in mitigating oxidative stress. Mutations in the SOD1 gene are linked to approximately 20% of familial amyotrophic lateral sclerosis (fALS) cases, a fatal neurodegenerative disorder. These mutations often induce toxic gain-of-function properties, leading to protein misfolding, aggregation, and motor neuron degeneration. SOD1 antibodies are essential tools in studying both normal and pathological SOD1 biology. They enable the detection of wild-type and mutant SOD1 isoforms in experimental models and patient samples, facilitating research into ALS mechanisms. Specific antibodies can distinguish between oxidized, reduced, or aggregated SOD1 forms, aiding in the characterization of disease-associated conformational changes. In therapeutic contexts, anti-SOD1 antibodies are explored for their potential to neutralize toxic SOD1 aggregates or enhance protein clearance. Some studies have investigated antibody-based therapies in preclinical ALS models, with mixed outcomes. Additionally, SOD1 antibodies are used diagnostically to differentiate fALS from sporadic ALS (sALS) and other neurodegenerative conditions. Their applications span Western blotting, immunohistochemistry, ELISA, and immunoprecipitation, making them indispensable for ALS research and drug development. Recent efforts focus on engineering antibodies with enhanced specificity for pathogenic SOD1 variants to improve diagnostic accuracy and therapeutic targeting.

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