| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | acng5 antibody; TARP gamma-5 antibody; Transmembrane AMPAR regulatory protein gamma-5 antibody |
| Entrez GeneID | 27091 |
| WB Predicted band size | Calculated MW: 31 kDa; Observed MW: 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic Peptide of L-type Ca++ CP γ5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Cav gamma 5(CACNG5)抗体的示例参考文献(部分内容为假设性概括，供参考)：
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1. **文献名称**：*"Voltage-gated calcium channels and auxiliary subunits: function and therapeutic potential"*
**作者**：Arikkath J, Campbell KP
**摘要**：综述了电压门控钙通道辅助亚基(包括Cavγ家族)的功能，指出Cav gamma 5(CACNG5)通过调节通道表面表达和电生理特性影响神经元兴奋性，并提及特异性抗体的开发用于检测其在脑组织中的分布。
2. **文献名称**：*"CACNG5 modulates calcium channel trafficking and synaptic plasticity in hippocampal neurons"*
**作者**：Chen Y et al.
**摘要**：利用Cav gamma 5特异性抗体，通过免疫印迹和免疫荧光技术，证实CACNG5在小鼠海马神经元中高表达，并发现其缺失导致钙通道稳定性下降及突触可塑性受损。
3. **文献名称**：*"Antibody-based profiling of Cavγ subunits in human neurological disorders"*
**作者**：Tian X et al.
**摘要**：研究采用抗Cav gamma 5的多克隆抗体分析癫痫患者脑组织样本，发现CACNG5蛋白表达显著降低，提示其可能与突触传递异常相关。
4. **文献名称**：*"Generation and characterization of monoclonal antibodies targeting Cavγ family members"*
**作者**：Burgess DL et al.
**摘要**：报道了针对Cavγ亚基(含gamma 5)的单克隆抗体制备，通过免疫沉淀和免疫组化验证抗体特异性，证实CACNG5在心脏和大脑中的差异性表达。
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**注**：以上为示例性内容，实际文献需通过数据库(如PubMed、Google Scholar)检索确认。建议使用关键词“CACNG5 antibody”或“Cav gamma 5 antibody”结合具体研究领域进行精准查询。
The Cavγ5 antibody targets the gamma-5 subunit (CACNG5) of voltage-gated calcium (Cav) channels, which are critical for regulating calcium influx in excitable cells. Cav channels consist of a pore-forming α1 subunit and auxiliary β, α2δ, and γ subunits. The γ subunits, encoded by the CACNG gene family, modulate channel trafficking, kinetics, and membrane expression. While γ subunits were initially identified in skeletal muscle, γ5 (CACNG5) shows broader expression, including the brain, heart, and pancreas, suggesting diverse functional roles beyond traditional channel regulation.
Cavγ5 is implicated in stabilizing channel complexes and influencing their pharmacological properties. Studies link γ5 to neurological and cardiovascular disorders, as altered calcium signaling contributes to conditions like epilepsy, arrhythmias, and neuropathic pain. However, γ5's specific mechanisms remain less characterized compared to other γ subunits (e.g., γ2 in AMPA receptor regulation).
Antibodies against Cavγ5 are essential tools for investigating its expression, localization, and interaction partners. They enable techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation, aiding in mapping its tissue distribution and disease-related changes. Commercial Cavγ5 antibodies are typically validated in knockout models or siRNA-treated cells to ensure specificity. Ongoing research focuses on clarifying γ5's role in Cav channel diversity and its potential as a therapeutic target, particularly in calcium-related pathologies.
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